Epidermal Lipids: Key Mediators of Atopic Dermatitis Pathogenesis
| Autor: | Nilika Bhattacharya, William J. Sato, Arup K. Indra, Avalon Kelly, Gitali Ganguli-Indra |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Skin barrier Ceramides Article Dermatitis Atopic Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine T-Lymphocyte Subsets medicine Animals Humans Molecular Biology integumentary system Cholesterol business.industry Cancer Atopic dermatitis Lipid Metabolism medicine.disease Normal functioning 030104 developmental biology Gene Expression Regulation chemistry Immunology Molecular Medicine lipids (amino acids peptides and proteins) Disease Susceptibility Epidermis business Biomarkers Metabolic Networks and Pathways 030217 neurology & neurosurgery |
| Zdroj: | Trends Mol Med |
| ISSN: | 1471-4914 |
| Popis: | Skin barrier keeps the “inside-in” and the “outside-out” forming a protective blanket against external insults. Epidermal lipids such as ceramides, fatty acids, triglycerides and cholesterol are integral components in driving the formation and maintenance of epidermal permeability barrier (EPB). A breach in this lipid barrier sets the platform for the subsequent onset and progression of atopic dermatitis (AD). Such lipids are also important in the normal functioning of different organisms, both plants and animals and in diseases including cancer. A double increase in AD rate in the recent years and the chronic nature of this disorder emphasizes the need of this review to shed light on the multifaceted role of the diverse types of lipids in mediating AD pathogenesis. |
| Databáze: | OpenAIRE |
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