Epidermal Lipids: Key Mediators of Atopic Dermatitis Pathogenesis

Autor: Nilika Bhattacharya, William J. Sato, Arup K. Indra, Avalon Kelly, Gitali Ganguli-Indra
Rok vydání: 2019
Předmět:
Zdroj: Trends Mol Med
ISSN: 1471-4914
Popis: Skin barrier keeps the “inside-in” and the “outside-out” forming a protective blanket against external insults. Epidermal lipids such as ceramides, fatty acids, triglycerides and cholesterol are integral components in driving the formation and maintenance of epidermal permeability barrier (EPB). A breach in this lipid barrier sets the platform for the subsequent onset and progression of atopic dermatitis (AD). Such lipids are also important in the normal functioning of different organisms, both plants and animals and in diseases including cancer. A double increase in AD rate in the recent years and the chronic nature of this disorder emphasizes the need of this review to shed light on the multifaceted role of the diverse types of lipids in mediating AD pathogenesis.
Databáze: OpenAIRE