Use quantitative parameters in spectral computed tomography for the differential diagnosis of metastatic mediastinal lymph nodes in lung cancer patients
| Autor: | Sushant Suwal, Huai Chen, Renli Cen, Zhiwen Ni, Hongjia Meng, Xiaoling Li, Suidan Huang |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Receiver operating characteristic medicine.diagnostic_test integumentary system business.industry Significant difference Computed tomography respiratory system medicine.disease Imaging data Mediastinal lymph node medicine Original Article Lymph Differential diagnosis Lung cancer Nuclear medicine business |
| Zdroj: | J Thorac Dis |
| ISSN: | 2072-1439 |
| Popis: | BACKGROUND: Accurate diagnosis of mediastinal lymph node (LN) metastases is very important for the treatment and prognosis in lung cancer patients. Spectral computed tomography (CT), as a non-invasive approach, has good prospects for detecting mediastinal nodal metastasis. However, the diagnostic criteria of differentiating metastatic and nonmetastatic LNs have not been determined. METHODS: Clinical and imaging data of 64 lung cancer patients (mean age 61.3±10.3 years, 41 men) from April to December 2019 were retrospectively analyzed. The unenhanced scan and contrast enhanced arterial phase (AP) and venous phase (VP) spectral CT scans were performed. The 70 keV monochromatic image and iodine-based image in all phases were analyzed to measure the parameters of LNs. LNs were divided into the metastatic and non-metastatic groups based on confirmative pathological results, and their differences were statistically analyzed. The receiver operating characteristics curve (ROC) was used to evaluate the efficacy of the differential diagnosis. RESULTS: Seventy-four metastatic LNs and 152 non-metastatic LNs were obtained. Compared with non-metastatic LNs, metastatic LNs often had a larger size (P |
| Databáze: | OpenAIRE |
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