S92. PREVALENCE AND SEVERITY OF THOUGHT DISORDER IN NON-PSYCHIATRIC CONTROLS
| Autor: | Heejong Sung, Jan E. Lerbinger, J. Alexander Bodkin, Deborah L. Levy, Charity J. Morgan, Michael J. Coleman, Fred Johnson |
|---|---|
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Schizophrenia Bulletin. 45:S341-S342 |
| ISSN: | 1745-1701 0586-7614 |
| DOI: | 10.1093/schbul/sbz020.637 |
| Popis: | BACKGROUND: Although thought disorder (TD) is a fundamental component of serious mental illness (SMI), qualitatively and quantitatively distinct TD phenotypes are associated with schizophrenia and bipolar disorder, both in patients and in their clinically unaffected biological relatives. Each TD phenotype shows relative specificity in relation to each disorder and with respect to familial aggregation. TD does occur in the general population, even one that has been screened for a personal or family history of psychosis, psychiatric hospitalization and suicide. METHODS: The Thought disorder Index (TDI) was administered to 242 individuals with a diagnosis of schizophrenia (SZ), 272 of their first-degree relatives (RelSZ), 79 individuals with a diagnosis of bipolar disorder (BPD) with psychotic features, 40 of their first-degree relatives, and 184 nonpsychiatric controls (NC). All patients were outpatients at the time of participation. All relatives were clinically unaffected. RESULTS: When TD occurs in nonpsychiatric controls, total TD scores are significantly lower in NC than in SZ patients and RelSZ and the proportion of NC with no TD is significantly higher than it is in SZ and RelSZ. Similarly, TD with “SZ features” (SZTD) and deviant verbalizations (the hallmark of SZTD) are also present in the general population, but at a significantly lower rate and in lower amounts than in SZ patients and RelSZ. Importantly, the SZTD phenotype shows significant heritability (higher relative risk) for SZ but not for bipolar disorder, both in patients and in clinically unaffected relatives, relative to NC despite the fact that some controls have TD. DISCUSSION: The presence of TD in NC is not sufficient to obscure the significant associations of TD phenotypes with SZ and BPD, biological risk for SZ and BPD, or their heritability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|