HIV Incidence and Risk Behaviours of People Who Inject Drugs in Bangkok, 1995-2012
| Autor: | Suphak Vanichseni, Manoj Leethochawalit, Philip A. Mock, Sithisat Chiamwongpaet, Somyot Kittimunkong, Jordan W. Tappero, Janet M. McNicholl, Kachit Choopanya, Frits van Griensven, Udomsak Sangkum, Punnee Pitisuttithum, Jaranit Kaewkungwal, Timothy D. Mastro, Michael Martin |
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| Rok vydání: | 2018 |
| Předmět: |
Placebo
01 natural sciences 03 medical and health sciences symbols.namesake 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Environmental health medicine 030212 general & internal medicine Poisson regression 0101 mathematics Prospective cohort study Tenofovir business.industry Incidence (epidemiology) 010102 general mathematics Vaccine trial Hiv incidence virus diseases HIV General Medicine medicine.disease Thailand HIV pre-exposure prophylaxis symbols business People who inject drugs Cohort study Research Paper |
| Zdroj: | EClinicalMedicine |
| ISSN: | 2589-5370 |
| Popis: | Background Three consecutive prospective studies were conducted among people who inject drugs (PWID) from May 1995 through June 2012 in Bangkok, Thailand. We examined data from these studies to evaluate HIV incidence and explore trends in risk behaviours. Methods We used data from a 1995–1998 cohort study, a 1999–2004 HIV vaccine trial, and a 2005–2012 HIV pre-exposure prophylaxis (PrEP) study to examine per-quarter trends in HIV incidence, using a restricted cubic spline function for time in a Poisson regression. We also examined temporal trends in HIV-associated risk behaviours. Findings HIV incidence declined from 5.7 per 100 person-years during the cohort study, to 2.7 per 100 person-years in the vaccine trial, to 0.7 per 100 person-years among PrEP study placebo recipients. Incidence peaked at 12.1 per 100 person-years in 1996 and declined to |
| Databáze: | OpenAIRE |
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