Elevated local production of neopterin from alveolar macrophages in patients with internal lung diseases
| Autor: | Takahiro Yamamoto, Toshiko Mouri, Dai Kurachi, Mitsuyo Saito, Shigenori Nakajima, Junichi Chihara |
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| Rok vydání: | 1996 |
| Předmět: |
Macrophage colony-stimulating factor
Adult medicine.medical_treatment Pulmonary Fibrosis In Vitro Techniques Neopterin chemistry.chemical_compound immune system diseases Macrophages Alveolar medicine Macrophage Humans Cells Cultured Pharmacology Lung business.industry Macrophage Colony-Stimulating Factor Respiratory disease respiratory system Macrophage Activation medicine.disease Biopterin medicine.anatomical_structure Cytokine chemistry Immunology Alveolar macrophage Interleukin-2 Pneumoconiosis Pulmonary alveolus business Lung Diseases Interstitial Bronchoalveolar Lavage Fluid |
| Zdroj: | General pharmacology. 27(3) |
| ISSN: | 0306-3623 |
| Popis: | 1. We measured the neopterin level in the supernatant of cultured alveolar macrophages from patients with interstitial lung diseases (ILD patients) as a marker for the activation of alveolar macrophage. 2. In ILD patients, the supernatant neopterin level (40.1 +/- 7.8 pmol/ml) was significantly higher (P0.01) than that in control subjects (10.0 +/- 1.6 pmol/ml). 3. We also found that macrophage-colony stimulating factor (M-CSF) and interleukin-2 (IL-2) augmented neopterin production from alveolar macrophage in both ILD patients (51.6 +/- 10.4 and 60.1 +/- 10.8 pmol/ml, respectively, P0.01) and control subjects (28.1 +/- 6.0 and 25.7 +/- 4.9 pmol/ml, respectively). 4. These findings suggest that alveolar macrophages produce neopterin by M-CSF or IL-2. |
| Databáze: | OpenAIRE |
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