What is the best sequence of chemotherapy in advanced colorectal cancer? Final results of a five-arm study
| Autor: | Dragana Babic, Zoran Krivokapic, Marjan Micev, Zdravko Zdrale, I. Popov, Svetislav Jelić |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Oncology
medicine.medical_specialty Time Factors Colorectal cancer medicine.drug_class medicine.medical_treatment Antineoplastic Agents Thymidylate synthase Antimetabolite Advanced colorectal cancer Cohort Studies Internal medicine Drug Discovery medicine Humans Pharmacology (medical) neoplasms Neoplasm Staging Pharmacology Chemotherapy biology business.industry General Medicine medicine.disease digestive system diseases Oxaliplatin Surgery Irinotecan Survival Rate stomatognathic diseases Infectious Diseases Fluorouracil biology.protein Disease Progression Drug Therapy Combination business Colorectal Neoplasms therapeutics hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Chemotherapy. 52(1) |
| ISSN: | 0009-3157 |
| Popis: | One hundred and ninety-three patients were assigned to receive 5-FU/LV, irinotecan and oxaliplatin in five different sequential treatment groups: Mayo Clinic Regimen (MCR) + LV5FU2 (group A); MCR + irinotecan (350 mg/m2) (group B); MCR + FOLFIRI (group C); MCR + FOLFOX4 (group D); FOLFIRI + FOLFOX4 (group E). The results were as follows: group A (32 patients), median overall survival (OS) 14 months, median time to progression (TTP1) 6 months, median TTP2 5 months, response rate (RR1) 22%, RR2 25%; group B (27 patients), OS 11 months, TTP1 6 months, TTP2 3 months, RR1 22%, RR2 19%; group C (43 patients), OS 14 months, TTP1 5 months, TTP2 5 months, RR1 12%, RR2 19%; group D (45 patients), OS 15 months, TTP1 5 months, TTP2 4 months, RR1 18%, RR2 20%; group E (46 patients), OS 19 months, TTP1 9 months, TTP2 5 months, RR1 39%, RR2 25%. There was a significant difference in OS (p < 0.005) between groups E vs. B and A, D vs. B. Sequential therapy with 3 active drugs (FOLFIRI + FOLFOX4) was the most efficacious combination in comparison with any other two drug combinations applied in our study. |
| Databáze: | OpenAIRE |
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