Increasing effect of a high dose of PG-1 peptide on the infectivity of Chlamydophila abortus
| Autor: | Raffaella Baldelli, Roberto Cevenini, Antonietta Di Francesco, Fabio Ostanello, Manuela Donati, Renato Gennaro, Monica Benincasa, Alisa Shurdhi, Maria Di Paolo |
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| Přispěvatelé: | Donati, M., Di Francesco, A., Gennaro, Renato, Benincasa, Monica, Di Paolo, M., Shurdhi, A., Ostanello, F., Baldelli, R., Cevenini, R., Donati M., Di Francesco A., Gennaro R., Benincasa M., Di Paolo M., Shurdhi A., Ostanello F., Baldelli R., Cevenini R. |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
Serotype Chlamydophila abortus Immunology Antimicrobial peptides medicine.disease_cause Microbiology Cell Line PG-1 Anti-Infective Agents medicine Animals Immunology and Allergy peptidi antimicrobici Chlamydiaceae catelicidine protegrina Inclusion Bodies Infectivity Chlamydophila biology General Medicine ANTIMICROBIAL PEPTIDES biology.organism_classification Antimicrobial Macaca mulatta Virology Infectious Diseases Chlamydia trachomatis Antimicrobial Cationic Peptides |
| Popis: | Cathelicidins are antimicrobial peptides, stored by mammalian leukocytes, showing an antimicrobial activity against bacteria, fungi, protozoa and enveloped viruses. In accordance with other authors, we reported in a previous study that the protegrin-1 (PG-1), at 80 microg mL(-1), inhibited the in vitro growth of Chlamydia trachomatis serovars D, H and L2; however, we observed an increased infectivity of some animal chlamydial species after their treatment with the same PG-1 concentration. In this study, the treatment of LLC-MK2 cells with PG-1 before chlamydial infection resulted in an increased infectivity of Chlamydophila abortus probably due to their easier entry into the host cells, whereas no increase in S26/3 infectivity was detected in LLC-MK2 cells treated with PG-1 postchlamydial infection. |
| Databáze: | OpenAIRE |
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