In vitro microbial metabolism of fumonisin B1
| Autor: | László Kametler, Rene Mamet, Judit Fodor, Melinda Kovács, Péter Horn, Ferenc Kovács, Johann Bauer, Christoph Gottschalk, Karsten Meyer |
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| Přispěvatelé: | Department of Animal Physiology, University of Kaposvár Faculty of Animal Science, Institute of Animal Hygiene, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM) |
| Rok vydání: | 2007 |
| Předmět: |
Swine
Health Toxicology and Mutagenesis Metabolite Carboxylic Acids Gut flora Toxicology digestive system Fumonisins Microbiology 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Biotransformation Fumonisin medicine Escherichia coli Animals Bacteroides Cecum Carcinogen 0303 health sciences Fumonisin B1 biology Hydrolysis Public Health Environmental and Occupational Health 030311 toxicology food and beverages Life Sciences 04 agricultural and veterinary sciences General Chemistry Metabolism biology.organism_classification 040401 food science Small intestine Carcinogens Environmental medicine.anatomical_structure chemistry Chemistry (miscellaneous) Food Science |
| Zdroj: | Food Additives and Contaminants Food Additives and Contaminants, 2007, 24 (04), pp.416-420. ⟨10.1080/02652030701216461⟩ |
| ISSN: | 0265-203X |
| DOI: | 10.1080/02652030701216461⟩ |
| Popis: | International audience; There is a lack of information on the effect of swine caecal microbiota on fumonisin metabolism. In this in vitro study, the biotransformation of fumonisin B1 (FB1) by the gut microbiota of adult, healthy pigs was examined. For that purpose, suspensions of caecal contents and McDougall buffer solution were incubated anaerobically with pure FB1 for 0, 12, 24, 48 and 72 h. In the 48th h, the conversion of FB1 into aminopolyols (46%) was nearly equal to the percental ratio of FB1, while in the 72nd h it was 49%. In vitro, the conversion of fumonisin B1 to aminopentol was less than 1%. Our results show that the caecal microbiota is able to transform fumonisin B1 to the above metabolites. Further studies on the presence of FB1 metabolism in the small intestine are clearly justified. |
| Databáze: | OpenAIRE |
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