Novel Structures of Functionalized Graphene Oxide with Hydrazide: Characterization and Bioevaluation of Antimicrobial and Cytocompatibility Features
| Autor: | Irina Zarafu, Carmen Limban, Cristiana Radulescu, Ioana Daniela Dulama, Diana Camelia Nuta, Cornel Chirita, Mariana Carmen Chifiriuc, Carmellina Daniela Badiceanu, Marcela Popa, Coralia Bleotu, Laura Denisa Dragu, Raluca Maria Stirbescu, Ioan Alin Bucurica, Sorina Geanina Stanescu, Petre Ionita |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Coatings, Vol 12, Iss 45, p 45 (2022) Coatings; Volume 12; Issue 1; Pages: 45 |
| ISSN: | 2079-6412 |
| Popis: | Graphite was oxidized to graphene oxide and activated by thionyl chloride, for further covalently linking three hydrazides with potential biological activity. The obtained materials were characterized by scanning electron microscopy with energy dispersive spectroscopy, Fourier-transform infrared and Raman spectroscopies. The presence of various functional groups specific to graphene oxide (GO) functionalized with different hydrazides was confirmed by spectral data. The ratio between D- and G-bands, observed in Raman spectra, allowed for an evaluation of the disorder degree and the mean crystallite size of the samples. The micrographs highlighted that the samples lead to the occurrence of disorders, probably caused by the sp3 carbons, the formation of oxygen-containing functional groups in the basal planes, and by various structural defects. The new graphene oxide–hydrazide derivatives were tested for their antimicrobial and cytotoxicity activity. Their antimicrobial activity against planktonic and biofilm-embedded cells was inferior to that of free hydrazides, except for GO-3 against planktonic Escherichia coli and GO-2 against Pseudomonas aeruginosa biofilm, demonstrating that further optimization is needed to be able to exploit the huge potential of GO for developing potent antimicrobials. |
| Databáze: | OpenAIRE |
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