Primary cytomegalovirus infection during pregnancy and congenital infection: a population-based, mother–child, prospective cohort study
Autor: | Tomoaki Ikeda, Hidemi Toyoda, Keishiro Amano, Kuniaki Toriyabe, Masako Kitano, Shigeru Suga, Toshio Minematsu, Sawako Masuda, Kyoko Shimada, Fumihiro Morikawa, Satoko Usui, Asa Kitamura, Makoto Ikejiri |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Adolescent Congenital cytomegalovirus infection Cytomegalovirus Pathogenesis Antibodies Viral Article 03 medical and health sciences 0302 clinical medicine Pregnancy Humans Medicine Avidity Prospective Studies 030212 general & internal medicine Pregnancy Complications Infectious Prospective cohort study Aged 030219 obstetrics & reproductive medicine biology business.industry Obstetrics Obstetrics and Gynecology medicine.disease Mother-Child Relations Confidence interval Risk factors Immunoglobulin M Relative risk Cytomegalovirus Infections Pediatrics Perinatology and Child Health biology.protein Female Antibody business Live birth |
Zdroj: | Journal of Perinatology |
ISSN: | 1476-5543 0743-8346 |
Popis: | Objective This study assessed maternal cytomegalovirus antibodies, and the occurrence of primary and congenital cytomegalovirus infections, and risk factors of congenital infection after a maternal primary infection. Study design We included 19,435 pregnant women in Japan, who were tested for serum cytomegalovirus antibodies before 20 gestational weeks. Immunoglobulin (Ig) G avidity was evaluated in women with both IgG and IgM antibodies; tests were repeated at ≥28 gestational weeks among women without IgG and IgM antibodies. Result Primary and congenital infections were 162 and 23 cases, respectively. The risk ratios for congenital infection were 8.18 (95% confidence interval: 2.44–27.40) in teenage versus older women, and 2.25 (95% confidence interval: 1.28–3.94) in parity ≥ 2 versus parity ≤ 1. Of 22 live birth congenital infection cases, three had abnormal neurological findings. Conclusion We demonstrated teenage and parity ≥ 2 pregnant women as risk factors of post-primary congenital infection. |
Databáze: | OpenAIRE |
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