Retinal asymmetry in multiple sclerosis
| Autor: | Petzold, Axel, Chua, Sharon Y. L., Khawaja, Anthony P., Keane, Pearse A., Khaw, Peng T., Reisman, Charles, Dhillon, Baljean, Strouthidis, Nicholas G., Foster, Paul J., Patel, Praveen J., Atan, Denize, Aslam, Tariq, Barman, Sarah A., Barrett, Jenny H., Bishop, Paul, Bunce, Catey, Carare, Roxana O., Chakravarthy, Usha, Chan, Michelle, Crabb, David P., Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew D., Egan, Cathy, Ennis, Sarah, Fruttiger, Marcus, Gallacher, John E. J., Garway-Heath, David F., Gibson, Jane, Gore, Dan, Guggenheim, Jeremy A., Hammond, Chris J., Hardcastle, Alison, Harding, Simon P., Hogg, Ruth E., Hysi, Pirro, Khaw, Sir Peng T., Lascaratos, Gerassimos, Lotery, Andrew J., MacGillivray, Tom, MacKie, Sarah, McGaughey, Michelle, McGuinness, Bernadette, McKay, Gareth J., McKibbin, Martin, Moore, Tony, Morgan, James E., Muthy, Zaynah A., O'Sullivan, Eoin, Owen, Chris G., Patel, Praveen, Paterson, Euan, Peto, Tunde, Rahi, Jugnoo S., Rudnikca, Alicja R., Self, Jay, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vitart, Veronique, Vernon, Stephen A., Viswanathan, Ananth C., Williams, Cathy, Williams, Katie, Woodside, Jayne V., Yates, Max M., Zheng, Yalin |
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| Přispěvatelé: | Consortium, UK Biobank Eye and Vision, Gallacher, JE, Neurology, Ophthalmology, APH - Mental Health, APH - Methodology, Amsterdam Neuroscience - Neuroinfection & -inflammation |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
genetic structures Youden's J statistic Optic neuritis Imaging chemistry.chemical_compound 0302 clinical medicine medicine.diagnostic_test AcademicSubjects/SCI01870 imaging Middle Aged Biobank Female demyelination Demyelination Tomography Optical Coherence medicine.medical_specialty Multiple Sclerosis Clinical Neurology Sensitivity and Specificity Retina Multiple sclerosis 03 medical and health sciences Optical coherence tomography SDG 3 - Good Health and Well-being Ophthalmology medicine Humans optic neuritis Research ethics Community level Neuromyelitis optica Receiver operating characteristic business.industry biomarkers Retinal Original Articles medicine.disease Confidence interval eye diseases chemistry North west 030221 ophthalmology & optometry Optometry AcademicSubjects/MED00310 RE Neurology (clinical) sense organs business 030217 neurology & neurosurgery Biomarkers RC |
| Zdroj: | UK Biobank Eye and Vision Consortium 2021, ' Retinal asymmetry in multiple sclerosis ', Brain, vol. 144, no. 1, pp. 224-235 . https://doi.org/10.1093/brain/awaa361 Brain Petzold, A, Chua, S Y L, Khawaja, A P, Keane, P A, Khaw, P T, Reisman, C, Dhillon, B, Strouthidis, N G, Foster, P J, Patel, P J, UK Biobank Eye and Vision Consortium, Atan, D, Aslam, T, Barman, S A, Barrett, J H, Bishop, P, Bunce, C, Carare, R O, Chakravarthy, U, Chan, M, Chua, S Y L, Crabb, D P, Day, A, Desai, P, Dhillon, B, Dick, A D, Egan, C, Ennis, S, Foster, P J, Fruttiger, M, Gallacher, J E J, Garway-Heath, D F, Gibson, J, Gore, D, Guggenheim, J A, Hammond, C J, Hardcastle, A, Harding, S P, Hogg, R E, Hysi, P, Keane, P A, Khaw, S P T, Khawaja, A P, Lascaratos, G, Lotery, A J, MacGillivray, T, MacKie, S, McGaughey, M, McGuinness, B, McKay, G J, McKibbin, M, Moore, T, Morgan, J E, Muthy, Z A, O'Sullivan, E, Owen, C G, Patel, P, Paterson, E, Peto, T, Petzold, A, Rahi, J S, Rudnikca, A R, Self, J, Sivaprasad, S, Steel, D, Stratton, I, Strouthidis, N, Sudlow, C, Thomas, D, Trucco, E, Tufail, A, Vitart, V, Vernon, S A, Viswanathan, A C, Williams, C, Williams, K, Woodside, J V, Yates, M M & Zheng, Y 2021, ' Retinal asymmetry in multiple sclerosis ', Brain, vol. 144, no. 1, pp. 224-235 . https://doi.org/10.1093/brain/awaa361 Brain : a journal of neurology Brain, 144(1), 224-235. Oxford University Press Petzold, A, Chua, S Y L, Khawaja, A P, Keane, P A, Khaw, P T, Reisman, C, Dhillon, B, Strouthidis, N G, Foster, P J & Patel, P J 2020, ' Retinal asymmetry in multiple sclerosis ', Brain . https://doi.org/10.1093/brain/awaa361 |
| ISSN: | 0006-8950 1460-2156 |
| Popis: | In a large community-based study, Petzold et al. show that optical coherence tomography measures of retinal asymmetry have high diagnostic sensitivity for multiple sclerosis, particularly in younger individuals without relevant comorbidities. The technique should be considered in future revisions of diagnostic criteria. The diagnosis of multiple sclerosis is based on a combination of clinical and paraclinical tests. The potential contribution of retinal optical coherence tomography (OCT) has been recognized. We tested the feasibility of OCT measures of retinal asymmetry as a diagnostic test for multiple sclerosis at the community level. In this community-based study of 72 120 subjects, we examined the diagnostic potential of the inter-eye difference of inner retinal OCT data for multiple sclerosis using the UK Biobank data collected at 22 sites between 2007 and 2010. OCT reporting and quality control guidelines were followed. The inter-eye percentage difference (IEPD) and inter-eye absolute difference (IEAD) were calculated for the macular retinal nerve fibre layer (RNFL), ganglion cell inner plexiform layer (GCIPL) complex and ganglion cell complex. Area under the receiver operating characteristic curve (AUROC) comparisons were followed by univariate and multivariable comparisons accounting for a large range of diseases and co-morbidities. Cut-off levels were optimized by ROC and the Youden index. The prevalence of multiple sclerosis was 0.0023 [95% confidence interval (CI) 0.00229–0.00231]. Overall the discriminatory power of diagnosing multiple sclerosis with the IEPD AUROC curve (0.71, 95% CI 0.67–0.76) and IEAD (0.71, 95% CI 0.67–0.75) for the macular GCIPL complex were significantly higher if compared to the macular ganglion cell complex IEPD AUROC curve (0.64, 95% CI 0.59–0.69, P = 0.0017); IEAD AUROC curve (0.63, 95% CI 0.58–0.68, P 0.14) with narrow confidence intervals. In conclusion, the OCT macular GCIPL complex IEPD and IEAD may be considered as supportive measurements for multiple sclerosis diagnostic criteria in a young patient without relevant co-morbidity. The metric does not allow separation of multiple sclerosis from neuromyelitis optica. Retinal OCT imaging is accurate, rapid, non-invasive, widely available and may therefore help to reduce need for invasive and more costly procedures. To be viable, higher sensitivity and specificity levels are needed. |
| Databáze: | OpenAIRE |
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