A novel strategy for the synthesis of 6H-chromeno [4, 3-b] quinoline by intramolecular Heck cyclization
| Autor: | Zahra Yasaei, Mina Fathollahi-Lahroud, Morteza Shiri |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Quinoline Intramolecular cyclization chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Indole Heck reaction Intramolecular force Drug Discovery Organic chemistry Triphenylphosphine Acetonitrile Intramolecular Heck Reaction Palladium 6H-chromeno [4 3-b] quinolines |
| DOI: | 10.6084/m9.figshare.13292738.v1 |
| Popis: | A novel procedure for the synthesis of various derivatives of 6H-chromeno [4, 3-b] quinolines from intramolecular Heck reaction of 2-chloro-3-(phenoxymethyl) quinolines is described in this study. Intramolecular cyclization of N-alkylated indoles was efficiently investigated as well. The reaction is catalyzed by bis (triphenylphosphine) palladium (II) dichloride in acetonitrile at 80 °C. |
| Databáze: | OpenAIRE |
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