Recipients who receive a human leukocyte antigen-B compatible cadaveric liver allograft are at high risk of developing acute graft-versus-host disease
| Autor: | J. Andrew Bradley, Craig J. Taylor, Anna L. Taylor, Tim Key |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Graft vs Host Disease Disease Human leukocyte antigen Antigen immune system diseases Risk Factors Odds Ratio Medicine Humans Transplantation Homologous Aged Retrospective Studies Transplantation business.industry Incidence Odds ratio Middle Aged Liver Transplantation surgical procedures operative HLA-B Antigens Histocompatibility Immunology Acute Disease Female Stem cell Cadaveric spasm business Complication |
| Zdroj: | Transplantation. 78(12) |
| ISSN: | 0041-1337 |
| Popis: | Acute graft-versus-host disease (GvHD) is an uncommon but often fatal complication after orthotopic liver transplantation (OLT). To determine whether there is an association between human leukocyte antigen (HLA) matching and the development of GvHD after cadaveric OLT, we undertook a retrospective, single-center analysis of 412 consecutive adult recipients where HLA typing data was available. Seven (1.7%) recipients developed acute GvHD, and six died from their disease. Donor compatibility at HLA-B but not at HLA-A or -DR was identified as a significant risk factor for the development of GvHD. Of 14 recipients with no HLA-B mismatches, 3 (21%) developed GvHD (odds ratio 27, P |
| Databáze: | OpenAIRE |
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