Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii

Autor:	Kenji Kubo, Hikaru Watanabe, Hiroyuki Kumeta, Tomoyasu Aizawa, Chigusa Seki, Hiroto Nakano, Kiyotaka Tokuraku, Koji Uwai
Rok vydání:	2022
Předmět:	Neurons Amyloid Amyloid beta-Peptides Plant Extracts Geranium Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Peptide Fragments Alzheimer Disease Drug Discovery Molecular Medicine Humans Molecular Biology
Zdroj:	Bioorganicmedicinal chemistry. 68
ISSN:	1464-3391
Popis:	Amyloid β (Aβ) aggregates in the brains of patients with Alzheimer's disease (AD) and accumulates via oligomerization and subsequent fiber elongation processes. These toxicity-induced neuronal damage and shedding processes advance AD progression. Therefore, Aβ aggregation-inhibiting substances may contribute to the prevention and treatment of AD. We screened for Aβ42 aggregation inhibitory activity using various plant extracts and compounds, and found high activity for a Geranium thunbergii extract (EC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad1f8ae5bcb2761f67de2e47a1de596 https://pubmed.ncbi.nlm.nih.gov/35661848 Zobrazit plný text záznamu Full Text from ScienceDirect