Autor: |
Kenji Kubo, Hikaru Watanabe, Hiroyuki Kumeta, Tomoyasu Aizawa, Chigusa Seki, Hiroto Nakano, Kiyotaka Tokuraku, Koji Uwai |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Bioorganicmedicinal chemistry. 68 |
ISSN: |
1464-3391 |
Popis: |
Amyloid β (Aβ) aggregates in the brains of patients with Alzheimer's disease (AD) and accumulates via oligomerization and subsequent fiber elongation processes. These toxicity-induced neuronal damage and shedding processes advance AD progression. Therefore, Aβ aggregation-inhibiting substances may contribute to the prevention and treatment of AD. We screened for Aβ42 aggregation inhibitory activity using various plant extracts and compounds, and found high activity for a Geranium thunbergii extract (EC |
Databáze: |
OpenAIRE |
Externí odkaz: |
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