Global analysis of bacterial transcription factors to predict cellular target processes
| Autor: | Tobias Doerks, Peer Bork, Warren C. Lathe, Miguel A. Andrade, Christian von Mering |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Genetics
Comparative genomics Bacteria fungi genetic processes Computational Biology Genomics Biology Metabolic pathway Databases as Topic Bacterial transcription Genes Bacterial Multigene Family Gene Order natural sciences Transcription factor Conserved Sequence Genome Bacterial Phylogeny Transcription Factors |
| Zdroj: | Trends in genetics : TIG. 20(3) |
| ISSN: | 0168-9525 |
| Popis: | Whole-genome sequences are now available for >100 bacterial species, giving unprecedented power to comparative genomics approaches. We have applied genome-context methods to predict target processes that are regulated by transcription factors (TFs). Of 128 orthologous groups of proteins annotated as TFs, to date, 36 are functionally uncharacterized; in our analysis we predict a probable cellular target process or biochemical pathway for half of these functionally uncharacterized TFs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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