Weight loss improves neurovascular and muscle metaboreflex control in obesity
| Autor: | Alfredo Halpern, Antonio Carlos Pereira Barretto, L. T. Batalha, Sandra M.F. Villares, Carlos Eduardo Negrão, Fátima H. S. Kuniyoshi, Márcia M. G. Gowdak, Ivani C. Trombetta, Maria Urbana P. B. Rondon, Mateus Camaroti Laterza |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty Sympathetic Nervous System Physiology Physical exercise Blood Pressure Weight loss Physiology (medical) Low calorie diet Internal medicine Reflex Weight Loss Medicine Humans Obesity Muscle Skeletal Exercise Hypocaloric diet Hand Strength business.industry Anthropometry Neurovascular bundle medicine.disease Plethysmography Forearm Endocrinology Blood Vessels Female medicine.symptom Cardiology and Cardiovascular Medicine business Energy Intake Body mass index Muscle Contraction |
| Zdroj: | American journal of physiology. Heart and circulatory physiology. 285(3) |
| ISSN: | 0363-6135 |
| Popis: | We studied the effects of a hypocaloric diet (D, n = 24, age: 32.2 ± 1.4 yr, body mass index: 34.7 ± 0.5 kg/m2) and a hypocaloric diet associated with exercise training (D + T, n = 25, age: 32.3 ± 1.3 yr, body mass index: 32.9 ± 0.4 kg/m2) on muscle metaboreflex control, muscle sympathetic nerve activity (MSNA, microneurography), blood pressure, and forearm blood flow (plethysmography) levels during handgrip exercise at 10% and 30% of maximal voluntary contraction in normotensive obese women. An additional 10 women matched by age and body mass index were studied as a nonadherent group. D or D + T significantly decreased body mass index. D or D + T significantly decreased resting MSNA (bursts/100 heartbeats). The absolute levels of MSNA were significantly lower throughout 10% and 30% exercise after D or D + T, although no change was found in the magnitude of response of MSNA. D + T, but not D, significantly increased resting forearm vascular conductance. D + T significantly increased the magnitude of the response of forearm vascular conductance during 30% exercise. D or D + T significantly increased MSNA levels during posthandgrip circulatory arrest when muscle metaboreflex is isolated. In conclusion, weight loss improves muscle metaboreflex control in obese women. Weight loss reduces MSNA, which seems to be centrally mediated. Weight loss by D + T increases forearm vascular conductance at rest and during exercise in obese individuals. |
| Databáze: | OpenAIRE |
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