β-lactam antibiotics & vancomycin increase the growth & virulence of Candida spp
| Autor: | Débora de Souza Collares Maia Castelo-Branco, Lilia Maria Carneiro Câmara, Patrícia Bruna Leite Mendes, Ana Raquel Colares de Andrade, Rossana de Aguiar Cordeiro, Lucas Pereira de Alencar, Jamille Alencar Sales, Marcos Fábio Gadelha Rocha, Jônatas da Silva Franco, Rosana Serpa, Jonathas Sales de Oliveira, José Júlio Costa Sidrim, Antonio José de Jesus Evangelista, Raimunda Sâmia Nogueira Brilhante |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Imipenem Antifungal Agents medicine.drug_class 030106 microbiology Antibiotics Virulence Microbial Sensitivity Tests beta-Lactams Candida parapsilosis Microbiology Candida tropicalis 03 medical and health sciences Vancomycin Candida krusei medicine Animals Humans Caenorhabditis elegans Candida albicans Candida biology Candidiasis biology.organism_classification Antimicrobial 030104 developmental biology medicine.drug |
| Zdroj: | Future Microbiology. 13:869-875 |
| ISSN: | 1746-0921 1746-0913 |
| DOI: | 10.2217/fmb-2018-0019 |
| Popis: | Aim: To investigate the direct effect of antibiotics on growth and virulence of the major Candida species associated with invasive infections. Materials & methods: Cefepime, imipenem, meropenem, amoxicillin and vancomycin were tested at twofold the peak plasma concentration (2× PP) and the peak plasma concentration (PP). The effects of antibiotics on Candida albicans, Candida parapsilosis, Candida krusei and Candida tropicalis were investigated by colony counting, flow cytometry, proteolytic activity and virulence in Caenorhabditis elegans. Results: Antibiotics increase growth and proteolytic activity of Candida spp; In addition, amoxicillin potentiates virulence of C. krusei and C. tropicalis against Caenorhabditis elegans. Conclusion: These results suggest that antimicrobial therapy may have a direct effect on the pathophysiology of invasive fungal infections in patients at risk. |
| Databáze: | OpenAIRE |
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