008 Circulating secreted phospholipase A2 activity: an early prognostic marker in unselected patients presenting to the emergency department with suspected acute coronary syndrome
| Autor: | Emmanuel Valentin, Monique Dehoux, Joelle Benessiano, Gabriel Steg, Pascale Bonnet, Armelle Desplanques |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Acute coronary syndrome business.industry Unstable angina Emergency department medicine.disease Chest pain Coronary artery disease Internal medicine Troponin I Cohort medicine Cardiology Myocardial infarction medicine.symptom business Cardiology and Cardiovascular Medicine |
| Zdroj: | Archives of Cardiovascular Diseases Supplements. (1):3 |
| ISSN: | 1878-6480 |
| DOI: | 10.1016/S1878-6480(10)70010-0 |
| Popis: | sPLA2 and Lp-PLA2 are currently being evaluated as potential markers and therapeutic targets in coronary artery disease. We hypothesized that their measurement, in parallel with CRP, could correlate to the risk of death or myocardial infarction (MI) in patients with suspected acute coronary syndromes (ACS), providing thereby important prognostic information. We therefore analysed a cohort of 419 unselected consecutive patients (mean 61.1 years old ; 63.9% male) presenting in the emergency room of a large tertiary hospital, without ST-segment elevation (NSTE) on the baseline ECG, with chest pain (72%) or other clinical features considered indicative of ACS. Clinical history, basal troponin I (cTnI) and CRP measurements were obtained. Final discharge diagnoses were assigned to the following categories: NSTE-ACS including NSTE-MI and unstable angina (UA), other cardiac diseases (OCD) or non cardiac diseases (NCD). Follow-up was obtained in all patients at 40 days. sPLA2 mass, sPLA2 and Lp-PLA2 activities were measured on the serum samples collected at presentation. The median sPLA2 activity was significantly higher in NSTE-ACS patients (1.89), than in OCP and NCP patients (1.45 and 1.43 respectively; p< 0.001). A significant association between sPLA2 mass and diagnosis (p |
| Databáze: | OpenAIRE |
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