Exposure to phthalate metabolites, phenols and organophosphate pesticide metabolites and blood pressure during pregnancy

Autor: Jeroen de Bont, Isabelle Pin, Sarah Lyon-Caen, Charline Warembourg, Xavier Basagaña, Valérie Siroux, Maribel Casas, Berit Granum, Cyntia B. Manzano-Salgado, Rémy Slama, Chiara Seminati, Cathrine Thomsen, Martine Vrijheid, Amrit Kaur Sakhi, Jose Urquiza
Přispěvatelé: Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), CIBER de Epidemiología y Salud Pública (CIBERESP), Norwegian Institute of Public Health [Oslo] (NIPH), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Service de chirurgie pédiatrique [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Université Grenoble Alpes (UGA), Siroux, Valérie, Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
Rok vydání: 2019
Předmět:
[SDE] Environmental Sciences
Physiology
Blood Pressure
Urine
010501 environmental sciences
01 natural sciences
chemistry.chemical_compound
MESH: Pregnancy
MESH: Phenols
0302 clinical medicine
Phthalates
Pregnancy
MESH: Organophosphorus Compounds
Organophosphate pesticides
030212 general & internal medicine
2. Zero hunger
Organophosphate
Phthalate
MESH: Blood Pressure
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
3. Good health
MESH: Environmental Pollutants
[SDE]Environmental Sciences
Gestation
Environmental Pollutants
Female
Biological Monitoring
Adult
Offspring
Phthalic Acids
03 medical and health sciences
Organophosphorus Compounds
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Phenols
medicine
Humans
MESH: Pesticides
Pesticides
Pregnancy Trimesters
0105 earth and related environmental sciences
MESH: Humans
business.industry
Public Health
Environmental and Occupational Health
MESH: Adult
MESH: Phthalic Acids
medicine.disease
Blood pressure
chemistry
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
MESH: Biological Monitoring
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
MESH: Female
Zdroj: International Journal of Hygiene and Environmental Health
International Journal of Hygiene and Environmental Health, Elsevier, 2019, 222 (3), pp.446-454. ⟨10.1016/j.ijheh.2018.12.011⟩
International Journal of Hygiene and Environmental Health, 2019, 222 (3), pp.446-454. ⟨10.1016/j.ijheh.2018.12.011⟩
ISSN: 1438-4639
Popis: International audience; Introduction: Hypertensive disorders during pregnancy are one of the leading causes of maternal and offspring mortality and morbidity. Exposure to environmental chemicals is suspected to increase blood pressure (BP) but few studies have investigated the impact of non-persistent chemicals, in particular among pregnant women.Methods: Women included in the study were 152 volunteer participants in the Human Early-Life Exposome (HELIX) project. They provided 3 urine samples daily over one week in two pregnancy trimesters (at around 18 and 32 weeks of gestation) to assess their exposure to phthalates (10 metabolites), phenols (7 compounds) and organophosphate pesticides (4 metabolites). BP was measured at the end of the two collection weeks. Associations between biomarkers of exposure and BP were investigated using generalized estimating equations (GEE) and linear regression, and adjusted for potential confounders.Results: A significant decrease in systolic and/or diastolic BP was observed with exposure to some phthalate metabolites, BPA, and parabens (e.g. β GEE models for systolic BP = -0.91 mmHg (95%CI: -1.65; -0.17) per doubling of BPA concentrations). These associations were more frequently observed in the second trimester of pregnancy and remained statistically significant after correction for multiple testing for BPA only. No associations were observed with organophosphate pesticides.Conclusion: This study investigates the effect of exposure to non-persistent chemicals assessed using multiple biospecimens per subject on BP during pregnancy and suggests that higher exposure to some phthalates and phenols but not pesticides is associated with lower BP during pregnancy.
Databáze: OpenAIRE
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