Erythropoietin Changes Contractility, cAMP, and Nitrite Levels of Isolated Rat Hearts
| Autor: | Ziya Kaygisiz, Nuray Yazihan, Kemal Sayar, Ruhi Uyar, Nilüfer Erkasap, Haluk Ataoglu, Murat Ikizler |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Inotrope medicine.medical_specialty Time Factors Physiology Rats Sprague-Dawley Contractility chemistry.chemical_compound Bolus (medicine) Heart Rate Internal medicine Heart rate Cyclic AMP medicine Animals Nitrite Erythropoietin Nitrites Dose-Response Relationship Drug business.industry Constant flow Myocardium Heart Stroke Volume Myocardial Contraction Rats Endocrinology chemistry Coronary perfusion pressure Female business medicine.drug |
| Zdroj: | The Journal of Physiological Sciences. 56:247-251 |
| ISSN: | 1880-6562 1880-6546 |
| Popis: | There is enough evidence that erythropoietin (EPO) may be involved in cardiovascular function. Therefore we have investigated the possible effects of EPO on left ventricular developed pressure, +dP/dt(max), heart rate, tissue cAMP, and nitrite levels. Isolated rat hearts were perfused under constant flow (10 ml/min) conditions with modified Krebs-Henseleit solution and recombinant human erythropoietin at doses of 100, 200, 500, and 1,000 IU/kg was administered as bolus injections. EPO at 100 IU/kg decreased, but higher doses (500 and 1,000 IU/kg) raised the developed pressure and +dP/dt(max). However, it did not affect heart rate or coronary perfusion pressure when all the respective doses were applied. EPO at 100 IU/kg increased nitrite, and at 1,000 IU/kg it raised cAMP. Our results suggest that EPO may produce dose-dependently negative and positive inotropic effects on myocardial contractility in isolated rat hearts. NO and cAMP may be involved in negative and positive inotropic effects of EPO, respectively. |
| Databáze: | OpenAIRE |
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