Gas Chromatographic Analysis of Cetiedil, a Candidate Antisickling Agent, in Human Plasma With Nitrogen-Sensitive Detection
Autor: | Vipul N. Mankad, Young W. Cho M.D., James D. Henderson, Thomas M. Glenn |
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Rok vydání: | 1984 |
Předmět: |
Adult
Male Chromatography Gas Chromatography Plasma samples Nitrogen Extraction (chemistry) Pharmaceutical Science chemistry.chemical_element Azepines Buffers Antisickling agents Kinetics chemistry.chemical_compound chemistry Antisickling Agents Human plasma Humans Gas chromatography Cetiedil Derivatization |
Zdroj: | Journal of Pharmaceutical Sciences. 73:1748-1751 |
ISSN: | 0022-3549 |
DOI: | 10.1002/jps.2600731222 |
Popis: | In this report a sensitive gas chromatographic assay for cetiedil, a candidate antisickling agent, in human plasma is described. After a triple extraction procedure, cetiedil was analyzed without derivatization with a nitrogen-phosphorus detector (with papaverine used as the internal standard.) Cetiedil was measured in plasma samples taken from human volunteers administered the drug intravenously. |
Databáze: | OpenAIRE |
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