Ambient carbon monoxide and daily mortality:a global time-series study in 337 cities
| Autor: | Antonella Zanobetti, Antonio Gasparrini, Joana Madureira, Matteo Scortichini, Bing-Yu Chen, Masahiro Hashizume, Michelle L. Bell, Joel Schwartz, Shanshan Li, Jouni J. K. Jaakkola, Christofer Åström, Ai Milojevic, Susanne Breitner, Ana M. Vicedo-Cabrera, Shilu Tong, Nicolás Valdés, Whanhee Lee, Carmen Iñiguez, Simona Fratianni, Alexandra Schneider, Niilo R.I. Ryti, Yueliang Leon Guo, Patricia Matus, Ho Kim, Massimo Stafoggia, Aurelio Tobias, Bertil Forsberg, Martina S. Ragettli, Francesco Sera, Yasushi Honda, Kathrin Wolf, Haidong Kan, Iulian Horia Holobâcă, Baltazar Nunes, Yuming Guo, Kai Chen, Eric Lavigne, Veronika Huber |
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| Přispěvatelé: | European Commission, Tobías, Aurelio [0000-0001-6428-6755], Instituto de Saúde Pública da Universidade do Porto, Tobías, Aurelio |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Health (social science) Ozone Air pollution Medicine (miscellaneous) Time Series 610 Medicine & health 010501 environmental sciences medicine.disease_cause 01 natural sciences Daily mortality Arbetsmedicin och miljömedicin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 360 Social problems & social services Air Pollution Environmental health Epidemiology Risk of mortality medicine Humans Nitrogen dioxide 030212 general & internal medicine Cities Air quality index lcsh:Environmental sciences 0105 earth and related environmental sciences MCC lcsh:GE1-350 Pollutant Air Pollutants Carbon Monoxide Health Policy Public Health Environmental and Occupational Health Public Health Global Health Social Medicine and Epidemiology Occupational Health and Environmental Health Particulates Ambient carbon monoxide Folkhälsovetenskap global hälsa socialmedicin och epidemiologi carbon monoxide mortality chemistry Cardiovascular Diseases Environmental science Determinantes da Saúde e da Doença Genotoxicidade Ambiental |
| Zdroj: | The Lancet Planetary Health Digital.CSIC. Repositorio Institucional del CSIC instname LANCET PLANETARY HEALTH r-FISABIO. Repositorio Institucional de Producción Científica The Lancet Planetary Health, Vol 5, Iss 4, Pp e191-e199 (2021) Lancet Planet Health 5, e191-e199 (2021) Chen, Kai; Breitner, Susanne; Wolf, Kathrin; Stafoggia, Massimo; Sera, Francesco; Vicedo-Cabrera, Ana M; Guo, Yuming; Tong, Shilu; Lavigne, Eric; Matus, Patricia; Valdés, Nicolás; Kan, Haidong; Jaakkola, Jouni J K; Ryti, Niilo R I; Huber, Veronika; Scortichini, Matteo; Hashizume, Masahiro; Honda, Yasushi; Nunes, Baltazar; Madureira, Joana; ... (2021). Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities. Lancet planetary health, 5(4), e191-e199. Elsevier 10.1016/S2542-5196(21)00026-7 Digital.CSIC: Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) |
| ISSN: | 2542-5196 |
| Popis: | Background Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a multicity, multicountry setting. Methods We collected daily data on air pollution, meteorology, and total mortality from 337 cities in 18 countries or regions, covering various periods from 1979 to 2016. All included cities had at least 2 years of both CO and mortality data. We estimated city-specific associations using confounder-adjusted generalised additive models with a quasi-Poisson distribution, and then pooled the estimates, accounting for their statistical uncertainty, using a random-effects multilevel meta-analytical model. We also assessed the overall shape of the exposure–response curve and evaluated the possibility of a threshold below which health is not affected. Findings Overall, a 1 mg/m3 increase in the average CO concentration of the previous day was associated with a 0·91% (95% CI 0·32–1·50) increase in daily total mortality. The pooled exposure–response curve showed a continuously elevated mortality risk with increasing CO concentrations, suggesting no threshold. The exposure–response curve was steeper at daily CO levels lower than 1 mg/m3, indicating greater risk of mortality per increment in CO exposure, and persisted at daily concentrations as low as 0·6 mg/m3 or less. The association remained similar after adjustment for ozone but was attenuated after adjustment for particulate matter or sulphur dioxide, or even reduced to null after adjustment for nitrogen dioxide. Interpretation This international study is by far the largest epidemiological investigation on short-term CO-related mortality. We found significant associations between ambient CO and daily mortality, even at levels well below current air quality guidelines. Further studies are warranted to disentangle its independent effect from other traffic-related pollutants. EU Horizon 2020, UK Medical Research Council, and Natural Environment Research Council |
| Databáze: | OpenAIRE |
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