Therapeutic 'Tool' in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair
| Autor: | Yiwei Wang, Shuangshuang Zheng, Liying Li, Wenfang Li, Jie Xu, Xueyan Hu, Yi Nie, Kedong Song, Roxanne Parungao, Tianqing Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cartilage
Articular 0106 biological sciences Cell Bone Marrow Cells Bioengineering Biology 01 natural sciences Applied Microbiology and Biotechnology Biochemistry Regenerative medicine Bone and Bones Tissue engineering Osteogenesis 010608 biotechnology medicine Animals Humans Regeneration Molecular Biology Cell Proliferation Bone Transplantation Tissue Engineering Tissue Scaffolds 010405 organic chemistry Stem Cells Regeneration (biology) Cell Differentiation Mesenchymal Stem Cells General Medicine Chondrogenesis 0104 chemical sciences medicine.anatomical_structure Subchondral bone Bone marrow Stem cell Biotechnology Biomedical engineering |
| Zdroj: | Applied Biochemistry and Biotechnology. 191:785-809 |
| ISSN: | 1559-0291 0273-2289 |
| Popis: | Repairing osteochondral defects to restore joint function is a major challenge in regenerative medicine. However, with recent advances in tissue engineering, the development of potential treatments is promising. In recent years, in addition to single-layer scaffolds, double-layer or multilayer scaffolds have been prepared to mimic the structure of articular cartilage and subchondral bone for osteochondral repair. Although there are a range of different cells such as umbilical cord stem cells, bone marrow mesenchyml stem cell, and others that can be used, the availability, ease of preparation, and the osteogenic and chondrogenic capacity of these cells are important factors that will influence its selection for tissue engineering. Furthermore, appropriate cell proliferation and differentiation of these cells is also key for the optimal repair of osteochondral defects. The development of bioreactors has enhanced methods to stimulate the proliferation and differentiation of cells. In this review, we summarize the recent advances in tissue engineering, including the development of layered scaffolds, cells, and bioreactors that have changed the approach towards the development of novel treatments for osteochondral repair. |
| Databáze: | OpenAIRE |
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