Study of the differentially abundant proteins among Leishmania amazonensis, L. braziliensis, and L. infantum

Autor: Simone da Fonseca Pires, Jonas Perales, Tiago Antônio de Oliveira Mendes, Alexander Chapeourouge, Hélida Monteiro de Andrade, Luiz Carlos Fialho-Júnior, Bruna Soares de Souza Lima, Barbara Beiral Esteves
Rok vydání: 2020
Předmět:
Proteomics
Life Cycles
Protein Extraction
Leishmania mexicana
Protozoan Proteins
Protozoology
Ribosome
Biochemistry
Medical Conditions
Zoonoses
Protein Interaction Mapping
Medicine and Health Sciences
Protein Interaction Maps
Leishmaniasis
chemistry.chemical_classification
Protozoans
Leishmania
Extraction Techniques
Multidisciplinary
Eukaryota
Arginase
Infectious Diseases
Medicine
Protein Interaction Networks
Protozoan Life Cycles
Transaldolase
Network Analysis
Research Article
Neglected Tropical Diseases
Computer and Information Sciences
Science
Leishmania Infantum
Enolase
Leishmaniasis
Cutaneous
Biology
Research and Analysis Methods
Microbiology
Leishmania braziliensis
Heat shock protein
medicine
Parasitic Diseases
Humans
DNA ligase
Protozoan Infections
Promastigotes
Organisms
Computational Biology
Biology and Life Sciences
medicine.disease
Tropical Diseases
Parasitic Protozoans
Health Care
Visceral leishmaniasis
chemistry
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240612 (2020)
ISSN: 1932-6203
Popis: Leishmaniasis has been considered as emerging and re-emerging disease, and its increasing global incidence has raised concerns. The great clinical diversity of the disease is mainly determined by the species. In several American countries, tegumentary leishmaniasis (TL) is associated with both Leishmania amazonensis and L. braziliensis, while visceral leishmaniasis (VL) is associated with L. (L.) infantum. The major molecules that determine the most diverse biological variations are proteins. In the present study, through a DIGE approach, we identified differentially abundant proteins among the species mentioned above. We observed a variety of proteins with differential abundance among the studied species; and the biological networks predicted for each species showed that many of these proteins interacted with each other. The prominent proteins included the heat shock proteins (HSPs) and the protein network involved in oxide reduction process in L. amazonensis, the protein network of ribosomes in L. braziliensis, and the proteins involved in energy metabolism in L. infantum. The important proteins, as revealed by the PPI network results, enrichment categories, and exclusive proteins analysis, were arginase, HSPs, and trypanothione reductase in L. amazonensis; enolase, peroxidoxin, and tryparedoxin1 in L. braziliensis; and succinyl-CoA ligase [GDP -forming] beta-chain and transaldolase in L. infantum.
Databáze: OpenAIRE
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