Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review
| Autor: | Cathelijne Alleman, Linda Nelsen, Bas C. P. van Dijk, Henrik Svedsater, Andreas Heddini, Janita Balradj |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Quality of life
Pulmonary and Respiratory Medicine medicine.medical_specialty Severity of Illness Index Exacerbations 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires Asthma Control Test Health care medicine Humans 030212 general & internal medicine Rescue medication Lung function Asthma lcsh:RC705-779 Clinical Trials as Topic business.industry lcsh:Diseases of the respiratory system Evidence-based medicine medicine.disease ACT Clinical trial 030228 respiratory system Asthma Control Questionnaire Family medicine Disease Progression business Research Article |
| Zdroj: | BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-9 (2020) BMC Pulmonary Medicine |
| ISSN: | 1471-2466 |
| DOI: | 10.1186/s12890-020-1090-5 |
| Popis: | Background The Asthma Control Test (ACT) has been used to assess asthma control in both clinical trials and clinical practice. However, the relationships between ACT score and other measures of asthma impact are not fully understood. Here, we evaluate how ACT scores relate to other clinical, patient-reported, or economic asthma outcomes. Methods A targeted literature search of online databases and conference abstracts was performed. Data were extracted from articles reporting ACT score alongside one or more of: Asthma Control Questionnaire (ACQ) score; rescue medication use; exacerbations; lung function; health−/asthma-related quality of life (QoL); sleep quality; work and productivity; and healthcare resource use (HRU) and costs. Results A total of 1653 publications were identified, 74 of which were included in the final analysis. Of these, 69 studies found that improvement in ACT score was related to improvement in outcome(s), either as correlation or by association. The level of evidence for each relationship differed widely between outcomes: substantial evidence was identified for relationships between ACT score and ACQ score, lung function, and asthma-related QoL; moderate evidence was obtained for relationships between ACT score and rescue medication use, exacerbations, sleep quality, and work and productivity; limited evidence was identified for relationships between ACT score and general health-related QoL, HRU, and healthcare costs. Conclusions Findings of this review suggest that the ACT is an appropriate measure for overall asthma impact and support its use in clinical trial settings. GlaxoSmithKline plc. study number HO-17-18170. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink