Subcellular distribution of phosphatases, proteinases, and ribonucleases in normal human stratum corneum and psoriatic scales
| Autor: | U. Fertig, K Bauer, G. Leonhardi, Anita Neufahrt, F.J. Förster, S Frenkel, G Stockum |
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| Rok vydání: | 1975 |
| Předmět: |
Cell Nucleus
Differential centrifugation chemistry.chemical_classification Cytoplasm integumentary system Phosphatase Dermatology General Medicine Hydrogen-Ion Concentration Biology Alkaline Phosphatase Phosphoric Monoester Hydrolases Subcellular distribution Ribonucleases medicine.anatomical_structure Enzyme chemistry Biochemistry Stratum corneum medicine Psoriasis Alkaline phosphatase Peptide Hydrolases Skin Subcellular Fractions |
| Zdroj: | Archives for Dermatological Research. 254:23-28 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/bf00561530 |
| Popis: | The subcellular distribution of phosphatases, proteinases, and ribonucleases of normal human stratum corneum and psoriatic scales was determined after differential centrifugation. All psoriatic enzymes showed much increased activities as compared to the normal stratum corneum enzymes. The highest activities of alkaline phosphatase from psoriatic scales could be detected in the nuclear fraction. The main activities of all other tested phosphatases and proteinases were present in the cytoplasmatic fraction. The subcellular distribution of the ribonucleases varied according to the pH value. |
| Databáze: | OpenAIRE |
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