3D printed personalized magnetic micromachines from patient blood–derived biomaterials
| Autor: | Mirac Nur Musaoglu, Zeynep Umut Kulali, Immihan Ceren Yasa, Hakan Ceylan, Nihal Olcay Dogan, Metin Sitti |
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| Přispěvatelé: | Sitti, Metin (ORCID 0000-0001-8249-3854 & YÖK ID 297104), Musaoğlu, Mirac Nur, Kulalı, Zeynep Umut, Ceylan, Hakan, Doğan, Nihal Olcay, Yaşa, İmmihan Ceren, College of Engineering, School of Medicine, Department of Mechanical Engineering |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Science Advances, 7 (36) Science Advances |
| ISSN: | 2375-2548 |
| Popis: | While recent wireless micromachines have shown increasing potential for medical use, their potential safety risks concerning biocompatibility need to be mitigated. They are typically constructed from materials that are not intrinsically compatible with physiological environments. Here, we propose a personalized approach by using patient blood-derivable biomaterials as the main construction fabric of wireless medical micromachines to alleviate safety risks from biocompatibility. We demonstrate 3D printed multiresponsive microswimmers and microrollers made from magnetic nanocomposites of blood plasma, serum albumin protein, and platelet lysate. These micromachines respond to time-variant magnetic fields for torque-driven steerable motion and exhibit multiple cycles of pH-responsive two-way shape memory behavior for controlled cargo delivery and release applications. Their proteinaceous fabrics enable enzymatic degradability with proteinases, thereby lowering risks of long-term toxicity. The personalized micromachine fabrication strategy we conceptualize here can affect various future medical robots and devices made of autologous biomaterials to improve biocompatibility and smart functionality. Science Advances, 7 (36) ISSN:2375-2548 |
| Databáze: | OpenAIRE |
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