Adverse changes in left ventricular structure begin at normotensive systolic blood pressures: a high resolution MRI study

Autor: Stuart A. Cook, Declan P. O'Regan, Antonio de Marvao, Daniel Rueckert, Wenzhe Shi, Timothy J W Dawes, Giuliana Durighel
Rok vydání: 2015
Předmět:
Zdroj: Journal of Cardiovascular Magnetic Resonance
ISSN: 1532-429X
Popis: Background The prevalence of hypertension has doubled over the previous decade and represents a significant public health problem worldwide. Excess cardiovascular risk due to increased blood pressure shows no evidence of a threshold to at least 115/75 mmHg. Left ventricular (LV) hypertrophy has a strong association with essential hypertension and is an independent risk factor for mortality. However, there is little data on whether systolic blood pressure (SBP) influences LV morphology and function in a healthy population. Furthermore it is not clear if any phenotypical changes are part of an adaptive response to increasing afterload or the beginning of a maladaptive process that ultimately leads to cardiomyopathy.
Databáze: OpenAIRE