Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies
| Autor: | Steve Gallinger, Sharon Buehler, Darshana Daftary, H B Younghusband, John R. McLaughlin, Patrick S. Parfrey, J. D. Robb, Roger C. Green, Jane Green |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Gerontology Cancer Research Amsterdam criteria medicine.medical_specialty Genes APC Newfoundland and Labrador Colorectal cancer Population Risk Assessment Familial adenomatous polyposis Epidemiology Genetics medicine Humans Genetic Predisposition to Disease Registries Age of Onset Family history education Germ-Line Mutation Genetics (clinical) Ontario Family Characteristics education.field_of_study business.industry Incidence Incidence (epidemiology) Neoplasms Second Primary Colonoscopy medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Lynch syndrome Pedigree MutS Homolog 2 Protein Adenomatous Polyposis Coli Oncology Population Surveillance Female Colorectal Neoplasms business Precancerous Conditions Demography |
| Zdroj: | Familial Cancer. 6:53-62 |
| ISSN: | 1573-7292 1389-9600 |
| DOI: | 10.1007/s10689-006-9104-x |
| Popis: | Newfoundland has the highest rate of colorectal cancer (CRC) of any Canadian province. In order to investigate the factors, especially genetic components, responsible for CRC we established the Newfoundland Colorectal Cancer Registry. In a 5-year period we examined every case of CRC diagnosed under the age of 75 years and obtained consent from 730 cases. Careful analysis of family history was used to assign a familial cancer risk, based on established criteria. We observed that 3.7% of CRC cases came from families meeting the Amsterdam II criteria and a further 0.9% of cases involved familial adenomatous polyposis (FAP). An additional 43% of cases met one or more of the revised Bethesda criteria and 31% of all cases had a first-degree relative affected with CRC. We compared the Newfoundland data with data from the province of Ontario, where the same recruitment and risk-assessment criteria were used. In all categories, the indicators of familial risk were significantly higher in Newfoundland. These data were also compared to results published from 13 other population-based studies worldwide. In every category the proportion of Newfoundland cases meeting the criteria was higher than in any other population. The mean differences were: 3.5-fold greater for FAP, 2.8-fold higher for Amsterdam criteria, 2.0-fold higher for Bethesda criteria and 1.9-fold higher for the number of affected first-degree relatives. We conclude that the high incidence of CRC in Newfoundland may be attributable to genetic, or at least familial, factors. In the high-risk families we provide evidence for the involvement of founder mutations in the APC and MSH2 genes. |
| Databáze: | OpenAIRE |
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