Improved nutritional status and bone health after diet-induced weight loss in sedentary osteoarthritis patients: a prospective cohort study
| Autor: | K. Winther, Henning Bliddal, B.F. Riecke, Arne Astrup, Else Marie Bartels, Robin Christensen, Pia Christensen, Anthony R. Leeds |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Bone density Population Medicine (miscellaneous) Nutritional Status Bone and Bones/metabolism Gastroenterology Bone and Bones Body Mass Index Weight loss Bone Density Internal medicine Weight Loss medicine Vitamin D and neurology Vitamin B 12/blood Humans Obesity Prospective Studies Vitamin D education Aged education.field_of_study Nutrition and Dietetics business.industry Ferritins/blood formula diet Middle Aged Osteoarthritis Knee Micronutrient medicine.disease Weight Reduction Programs osteoarthritis Vitamin B 12 Endocrinology Osteoarthritis Knee/blood Vitamin D/blood Ferritins Lean body mass Body Composition Original Article Female medicine.symptom Obesity/complications business Energy Intake Body mass index |
| Zdroj: | European Journal of Clinical Nutrition Christensen, P, Bartels, E M, Riecke, B F, Bliddal, H, Leeds, A R, Astrup, A, Winther, K & Christensen, R 2012, ' Improved nutritional status and bone health after diet-induced weight loss in sedentary osteoarthritis patients : a prospective cohort study ', European Journal of Clinical Nutrition, vol. 66, no. 4, pp. 504-509 . https://doi.org/10.1038/ejcn.2011.201 |
| ISSN: | 1476-5640 0954-3007 |
| DOI: | 10.1038/ejcn.2011.201 |
| Popis: | BACKGROUND/OBJECTIVES: Obese subjects are commonly deficient in several micronutrients. Weight loss, although beneficial, may also lead to adverse changes in micronutrient status and body composition. The objective of the study is to assess changes in micronutrient status and body composition in obese individuals after a dietary weight loss program.SUBJECTS/METHODS: As part of a dietary weight loss trial, enrolling 192 obese patients (body mass index >30 kg/m2) with knee osteoarthritis (>50 years of age), vitamin D, ferritin, vitamin B12 and body composition were measured at baseline and after 16 weeks. All followed an 8-week formula weight-loss diet 415-810 kcal per day, followed by 8 weeks on a hypo-energetic 1200 kcal per day diet with a combination of normal food and formula products. Statistical analyses were based on paired samples in the completer population.RESULTS: A total of 175 patients (142 women), 91%, completed the 16-week program and had a body weight loss of 14.0 kg (95% confidence interval: 13.3-14.7; PCONCLUSIONS: This intensive program with formula diet resulted in increased BMD and improved vitamin D and B12 levels. Ferritin and BMC were unchanged and loss of LBM was only 13% of the total weight loss. This observational evidence supports use of formula diet-induced weight loss therapy in obese osteoarthritis patients. |
| Databáze: | OpenAIRE |
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