Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
| Autor: | Silvia Pesenti, Silvia Ministrini, Michele Magoni, Nazario Portolani, Sarah Molfino, Marco Moneda, Angelo Rossini, Giuseppe De Palma, Alice Gaia, Claudio Sileo, Elena Zanardini, Francesco Donato, Giovanni Battista Contessi |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Carcinoma Hepatocellular Epidemiology Science Population Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors Internal medicine Animals Humans Medicine Liver damage education Carcinogen Cancer Aged Aged 80 and over education.field_of_study Multidisciplinary Hepatology business.industry Melanoma Liver Neoplasms Translational research Middle Aged medicine.disease Polychlorinated Biphenyls Carcinogens Environmental Rats Lymphoma Environmental sciences 030104 developmental biology Italy Liver Hepatocellular carcinoma Female 030211 gastroenterology & hepatology Environmental Pollution business Liver cancer |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Polychlorinated biphenyls (PCBs) are human carcinogens, based on sufficient evidence for melanoma and limited evidence for non-Hodgkin lymphoma and breast cancer. Few data are available for liver cancer, although PCBs cause it in rats and determined liver damage in poisoned people. We investigated the association between PCB serum levels and hepatocellular carcinoma (HCC) with a case–control study in a PCB-polluted area in North Italy. We enrolled prospectively 102 HCC incident cases and 102 age and gender-matched hospital controls. Serum concentrations of 33 PCB congeners were determined by a gas chromatograph coupled to mass spectrometry. Of 102 HCC cases, 62 who had lost 1.5 or 2 were found, although the 95% CIs included the null value for almost all of them. This preliminary study suggests that PCBs might play a role in HCC development. |
| Databáze: | OpenAIRE |
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