Phototoxicity from furocoumarins (psoralens) ofHeracleum laciniatumin a patient with vitiligo. Action spectrum studies on bergapten, pimpinellin, angelicin and sphondin
| Autor: | K. Midelfart, G. Kavli, G. Volden, J. Raa |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
medicine.medical_specialty Ultraviolet Rays Vitiligo Dermatology Pharmacology Radiation Dosage Bergapten chemistry.chemical_compound Isomerism Angelicin Furocoumarins medicine Humans Immunology and Allergy Potency Photosensitivity Disorders Action spectrum biology biology.organism_classification medicine.disease Intercalating Agents Plants Toxic Tranquilizing Agents Heracleum chemistry 5-Methoxypsoralen Methoxsalen Anticonvulsants Female Spectrophotometry Ultraviolet Phototoxicity |
| Zdroj: | Contact Dermatitis. 9:364-366 |
| ISSN: | 0105-1873 |
| DOI: | 10.1111/j.1600-0536.1983.tb04429.x |
| Popis: | Investigations on light reactions in a patient with vitiligo are presented. The minimal erythema dose (MED) in the UVB area was approximately 1/3 of that in persons of skin type II. The application of furocoumarins (psoralens) increased light tolerance by 1 MED at 300-310 nm. Action spectrum studies with furocoumarins from Heracleum laciniatum showed the following order of potency: bergapten, pimpinellin, angelicin and sphondin. The efficacy was highest at 325-350 nm, with maxima at 330-335 nm. Pimpinellin was recently found to be phototoxic, but an action spectrum of sphondin is reported for the first time. |
| Databáze: | OpenAIRE |
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