Correlations Between Polymorphisms of Extracellular Superoxide Dismutase, Aldehyde Dehydrogenase-2 Genes, as Well as Drinking Behavior and Pancreatic Cancer
| Autor: | Yongmei Qin, Chao-xian Zhang, Li-ke Guo |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Alcohol Drinking Aldehyde dehydrogenase Polymerase Chain Reaction law.invention Superoxide dismutase Risk Factors law Internal medicine Pancreatic cancer Genotype Humans Medicine Gene Polymerase chain reaction DNA Primers ALDH2 Genetics Polymorphism Genetic Base Sequence biology Superoxide Dismutase business.industry General Medicine Aldehyde Dehydrogenase Middle Aged medicine.disease Pancreatic Neoplasms Endocrinology biology.protein Female Restriction fragment length polymorphism business Polymorphism Restriction Fragment Length |
| Zdroj: | Chinese Medical Sciences Journal. 29:162-166 |
| ISSN: | 1001-9294 |
| DOI: | 10.1016/s1001-9294(14)60062-6 |
| Popis: | To investigate the correlation between drinking behavior combined with polymorphisms of extracellular superoxide dismutase (EC-SOD) and aldehyde dehydrogenase-2 (ALDH2) genes and pancreatic cancer.The genetic polymorphisms of EC-SOD and ALDH2 were analyzed by polymerase chain reaction restriction fragment length polymorphism in the peripheral blood leukocytes obtained from 680 pancreatic cancer cases and 680 non-cancer controls. Subsequently the frequency of genotype was compared between the pancreatic cancer patients and the healthy controls.The relationship of drinking with pancreatic cancer was analyzed.The frequencies of EC-SOD (C/G) and ALDH2 variant genotypes were 37.35% and 68.82% respectively in the pancreatic cancer cases, and were significantly higher than those in the healthy controls (21.03% and 44.56%, all P0.01). People who carried EC-SOD (C/G) (OR=2.24, 95% CI= 1.81-4.03, P0.01) or ALDH2 variant genotypes (OR=2.75, 95% CI=1.92-4.47, P0.01) had a high risk to develop pancreatic cancer. Those who carried EC-SOD (C/G) genotype combined with ALDH2 variant genotype had a high risk for pancreatic cancer (29.56% vs. 6.76%, OR=7.69, 95% CI=3.58-10.51, P0.01). The drinking rate of the pancreatic cancer group (64.12%) was significantly higher than that of the control group (40.15%; OR=2.66, 95% CI=1.30-4.42, P0.01). An interaction between drinking and EC-SOD (C/G)/ALDH2 variant genotypes increased the risk of occurrence of pancreatic cancer (OR=25.00, 95% CI= 11.87-35.64, P0.01).EC-SOD (C/G), ALDH2 variant genotypes and drinking might be the risk factors of pancreatic cancer. |
| Databáze: | OpenAIRE |
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