Racial and Ethnic Differences in an Estimated Measure of Insulin Resistance Among Individuals With Type 1 Diabetes
| Autor: | Melinda L. Drum, Carmela L. Estrada, Rebecca B. Lipton, Kirstie K. Danielson |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Type 2 diabetes Ethnic origin Diagnostic Techniques Endocrine Young Adult Insulin resistance Diabetes mellitus Internal medicine Ethnicity Internal Medicine medicine Humans Pathophysiology/Complications Child Acanthosis nigricans Original Research Advanced and Specialized Nursing Type 1 diabetes Parental obesity business.industry Insulin Racial Groups medicine.disease Diabetes Mellitus Type 1 Endocrinology Child Preschool Female Insulin Resistance business Demography |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc09-1220 |
| Popis: | OBJECTIVE Insulin resistance is greater in racial/ethnic minorities than in non-Hispanic whites (NHWs) for those with and without type 2 diabetes. Because previous research on insulin resistance in type 1 diabetes was limited to NHWs, racial/ethnic variation in an estimated measure of insulin resistance in type 1 diabetes was determined. RESEARCH DESIGN AND METHODS The sample included 79 individuals with type 1 diabetes diagnosed at age RESULTS Mean current age was 13.5 years (range 3.2–32.5) and diabetes duration was 5.7 years (0.1–19.9). eGDR was inversely associated with age. Compared with that in NHWs, age-adjusted eGDR was significantly lower among nonwhites (NHB, other/mixed, and Hispanic: Δ = −1.83, P = 0.0006). Age-adjusted eGDR was negatively associated with body fat, triglycerides, urinary albumin/creatinine, acanthosis nigricans, parental obesity, and parental insulin resistance and positively related to HDL and sex hormone–binding globulin. In multivariable analysis, lower eGDR was significantly associated with older age, nonwhite race/ethnicity, acanthosis, and lower HDL. CONCLUSIONS Minorities with type 1 diabetes are significantly more insulin resistant, as measured by eGDR, than NHWs. Exploring potential mechanisms, including disparities in care and/or physiological variation, may contribute to preventing racial/ethnic differences in insulin resistance–associated outcomes. |
| Databáze: | OpenAIRE |
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