IL-6 AND LIPOPROTEIN (a) [LP(a)] CONCENTRATIONS ARE RELATED ONLY IN PATIENTS WITH HIGH APO(a) ISOFORMS IN MONOCLONAL GAMMOPATHY
| Autor: | Elöd László, Puskás E, Gabriella Halm, László Kalabay, László Romics, George Füst, Laura Horváth, Katalin Pálóczi, András Falus, Albert Császár, Hans Dieplinger, Anna Horváth, Aniko Banyai |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Gene isoform medicine.medical_specialty Immunology Paraproteinemias Enzyme-Linked Immunosorbent Assay Biochemistry Polymorphism (computer science) Internal medicine medicine Humans Protein Isoforms Immunology and Allergy Interleukin 6 Molecular Biology Apolipoproteins A Aged Polymorphism Genetic biology Interleukin-6 Chemistry Acute-phase protein Case-control study Interleukin Hematology Lipoprotein(a) Middle Aged Endocrinology Case-Control Studies biology.protein Female lipids (amino acids peptides and proteins) Waldenstrom Macroglobulinemia Multiple Myeloma Lipoprotein |
| Zdroj: | Cytokine. 18:340-343 |
| ISSN: | 1043-4666 |
| DOI: | 10.1006/cyto.2002.1044 |
| Popis: | We have investigated the influence of apo(a) genetics on the relationship between interleukin (IL)-6, and lipoprotein (a) [Lp(a)] levels in 154 patients with monoclonal gammopathy and 189 healthy subjects. No significant differences in Lp(a) levels and distribution of subjects with different sizes of apo(a) isoforms were found between patients and healthy controls. Relationship between IL-6 and Lp(a) levels was strongly dependent on the size of apo(a) isoforms. In patients with high-size apo(a) isoforms Lp(a) levels positively correlated (r=0.475, P=0.0007) to IL-6 concentrations, whereas no correlation was found in patients with low apo(a) isoforms. Our present finding may provide a plausible explanation for the contradictory findings about the acute phase protein nature of Lp(a). |
| Databáze: | OpenAIRE |
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