Touch Preparation Cytological Evaluation of Radical Prostatectomy Specimens
| Autor: | Denise Hidvegi, Debra M. Sutkowski, Alfred W. Rademaker, Margaret S. Pearle, Ricardo S. Cajulis, Ryoichi Oyasu, John T. Grayhack, Kevin T. McVary |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Urology medicine.medical_treatment Specimen Handling Prostate cancer Cytology medicine Carcinoma Humans Prospective Studies Stage (cooking) Prospective cohort study Aged Neoplasm Staging Prostatectomy Histocytological Preparation Techniques Epithelioma business.industry Prostate Prostatic Neoplasms Histology Prognosis medicine.disease Surgery Radiology Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Journal of Urology. 152:124-128 |
| ISSN: | 1527-3792 0022-5347 |
| Popis: | The failure of current histological techniques to predict local failure and disease progression after radical prostatectomy is supported by substantial evidence. Moreover, the characterization of histological findings is hampered by the lack of uniform interpretation. We report a prospective study of 92 patients undergoing radical prostatectomy for clinical stages A and B prostate cancer in which the technique of touch preparation cytological analysis of surgical margins is compared to the standard histological approach. We evaluated 47 pathological stage B, 43 stage C and 2 stage D specimens. Specimens initially assigned to pathological stage B were upstaged to stage C on review by 1 blinded pathologist in 19 of 65 cases (29%). Overall, 15 of 47 histological stage B specimens (32%), 20 of 43 histological stage C specimens (47%) and 2 of 2 histological stage D specimens (100%) had malignant cells identified on the margins by touch preparation cytology. Postoperative mean followup of 7 months (range 0.4 to 26) revealed that 7 of 14 nonstage D cancer patients (50%) with elevated serum prostate specific antigen levels had positive cytology results, including 1 with histologically confirmed organ-confined disease. Among the stage C specimens cytology was more likely to be positive if there was concomitant seminal vesicle invasion. Correlation of this information with eventual patient course during the long term will be necessary to assess its role in patient management. |
| Databáze: | OpenAIRE |
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