Pentraxin-3 Serum Levels Are Associated with Disease Severity and Mortality in Patients with Systemic Inflammatory Response Syndrome
| Autor: | Ying Jie Ma, Jens J. Strøm, Peter Garred, Mikkel-Ole Skjoedt, Simone Bastrup-Birk, Lea Munthe-Fog |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent lcsh:Medicine Systemic inflammation Severity of Illness Index Gastroenterology law.invention Sepsis Young Adult Reference Values law Internal medicine medicine Humans lcsh:Science Aged Aged 80 and over Multidisciplinary biology Septic shock business.industry lcsh:R C-reactive protein Hazard ratio Area under the curve Middle Aged Prognosis medicine.disease Shock Septic Intensive care unit Recombinant Proteins Systemic Inflammatory Response Syndrome Systemic inflammatory response syndrome Serum Amyloid P-Component C-Reactive Protein ROC Curve Case-Control Studies Immunology biology.protein lcsh:Q Female medicine.symptom business Biomarkers Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 9, p e73119 (2013) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0073119 |
| Popis: | The long pentraxin-3 (PTX3) is a key component of the humoral arm of the innate immune system. PTX3 is produced locally in response to pro-inflammatory stimuli. To investigate PTX3 levels and its use as a biomarker in patients with systemic inflammation, we developed a solid-phase enzyme-linked immunosorbent assay based on novel anti-PTX3 monoclonal antibodies detecting PTX3 with high sensitivity. The assay was applied on 261 consecutive patients admitted to an intensive care unit prospectively monitored with the systemic inflammatory response syndrome (SIRS). 100 blood donors were included as controls. PTX3 levels were elevated in patients (median = 71.3 ng/ml) compared with the controls (median = 0 ng/ml) (Mann-Whitney, p |
| Databáze: | OpenAIRE |
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