Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms
| Autor: | Tzer Hwai Gilbert Thio, Marc J. Madou, Lawrence Kulinsky, Fatimah Ibrahim, Wisam Al-Faqheri, Salar Soroori, Norhayati Soin |
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| Rok vydání: | 2013 |
| Předmět: |
Compact Disks
Engineering Miniaturization Capillary action business.industry Microfluidics Biomedical Engineering Compact disc Centrifugation Equipment Design Mechanics Models Theoretical Aspect ratio (image) Article Computer Science Applications Physics::Fluid Dynamics Hydrodynamics Electronic engineering Meniscus Hydraulic diameter business Algorithms Communication channel |
| Zdroj: | Medical & Biological Engineering & Computing. 51:525-535 |
| ISSN: | 1741-0444 0140-0118 |
| DOI: | 10.1007/s11517-012-1020-7 |
| Popis: | This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. The implicit assumptions and limitations of these models are discussed. The fluid meniscus dynamics before bursting is broken up into a multi-stage model and a more accurate version of the burst frequency equation for the capillary valves is proposed. The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter, the height to width aspect ratio, and the opening wedge angle of the channel on the burst pressure. |
| Databáze: | OpenAIRE |
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