The combined action of rauscher leukemia virus and lactic dehydrogenase virus on mouse lymphatic tissue
| Autor: | Max Rowland Proffitt, C. C Congdon, R. L. Tyndall |
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| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Lymphoid Tissue viruses Spleen Thymus Gland Virus Replication Rauscher Virus Virus Microbiology Mice Immune system Immunity medicine Animals RNA Viruses Immunosuppression Therapy Immunity Cellular Hyperplasia biology Germinal center biology.organism_classification Virology Immunoblast medicine.anatomical_structure Rickettsia Oncology Cell culture Lymph Nodes |
| Zdroj: | International Journal of Cancer. 9:193-211 |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | Mice inoculated with animal-passaged Rauscher leukemia virus contaminated with lactic dehydrogenase virus showed early gross and histological changes in their lymphatic tissues comparable to those in mice inoculated with lactic dehydrogenase virus alone. Some of the changes closely resembled those that have been ascribed to stress, which are mediated by corticosteroid hormones Except for early erythroblast activation, mice inoculated with a pool of animal-passaged Rauscher leukemia virus derived from cell culture and not contaminated with lactic dehydrogenase virus did not undergo these changes. Most notable were the absence of early lymphocyte destruction in thymus-dependent areas responsible for cell-mediated immunity and the lack of significant immunoblast activation and proliferation in lymphoid germinal centers (humoral immune compartment). The presence of lactic dehydrogenase virus in Rauscher leukemia virus pools or its addition to the uncontaminated pool resulted in an enhancement of the “erythro-blastic reaction” associated with Rauscher disease, as indicated by an increase in spleen weight. There was also prominent diffuse and persisting hyperplasia of germinal center cells (immunoblasts and immunocytes) after lactic dehydrogenase virus was added to the uncontaminated Rauscher virus pool. Furthermore, the presence of the lactic dehydrogenase virus enhanced the immunosuppressive properties of Rauscher leukemia virus. Two possibilities were considered to account for the enhancement of Rauscher disease by lactic dehydrogenase virus. First, by stimulating germinal center hyperplasia, the virus could supply greater numbers of target cells for Rauscher virus replication. Second, the depression of the cell-mediated immune response by lactic dehydrogenase virus could prevent the inactivation of Rauscher virus particles, or tumor cells by lymphocytes. |
| Databáze: | OpenAIRE |
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