Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module
| Autor: | Krzysztof Kilian, Julia Juszczyk, Anna Pękal |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Nuclear and High Energy Physics
gas phase iodination 11c-methionine 11c-radiopharmaceuticals Science Halogenation 11c methionine 010403 inorganic & nuclear chemistry Condensed Matter Physics 01 natural sciences 030218 nuclear medicine & medical imaging 0104 chemical sciences Gas phase 03 medical and health sciences 0302 clinical medicine Nuclear Energy and Engineering Organic chemistry Safety Risk Reliability and Quality Waste Management and Disposal Instrumentation |
| Zdroj: | Nukleonika, Vol 61, Iss 1, Pp 29-33 (2016) |
| ISSN: | 0029-5922 |
| DOI: | 10.1515/nuka-2016-0007 |
| Popis: | A method of 11C-methionine synthesis using ‘bubbling’ method is presented. 11C-methionine was synthesized via 11C methylation from L-cysteine thiolactone (2 mg) in a 300 μL solution of 2:1:1 (v/v) 1 M NaOH, ethanol, and water at ambient temperature (85°C, 5 min). The radiochemical purity of radiotracer was higher than 99% and enantiomeric purity (L-11C-methionine) was 91.6 ± 0.4%. The final product met the requirements of European Pharmacopoeia monograph. The proposed 11C-methionine synthesis is a reliable tool for routine manufacturing in clinical applications and animal studies. |
| Databáze: | OpenAIRE |
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