Common Quantitative Trait Loci for Alcohol-Related Behaviors and CNS Neurotensin Measures: Voluntary Ethanol Consumption

Autor:	Vaughn M. Gehle, V. Gene Erwin
Rok vydání:	1998
Předmět:	Genetics Medicine (miscellaneous) Quantitative genetics Biology Quantitative trait locus Toxicology Phenotype Psychiatry and Mental health chemistry.chemical_compound chemistry Gene mapping Polymorphism (computer science) Genetic model Neurotensin receptor Neurotensin
Zdroj:	Alcoholism: Clinical and Experimental Research. 22:401-408
ISSN:	1530-0277 0145-6008
DOI:	10.1111/j.1530-0277.1998.tb03666.x
Popis:	The C57BL/6, DBA/2, and recombinant inbred (RI) strains derived from them (BxD Rls) are the most frequently studied mouse strains with regard to genetic regulation of voluntary ethanol consumption (VEC). We have studied VEC in an alternate genetic model provided by the LSxSS Rls. These RI strains exhibit phenotypic extremes in VEC comparable to the C57BL/6 and DBA/2 mice and genotype-dependent sex differences in drinking behavior. A correlational analysis between various ethanol-related behaviors suggests genetic independence of VEC from high-dose neurosensitivity (sleep time), acute ethanol tolerance, hypothermia, and low-dose locomotor activity. A search for quantitative trait loci identified a number of putative quantitative trait loci (QTL), three of which are identical to those previously reported for 10% ethanol drinking in the BxD RIs. We also find a significant correlation between low-affinity neurotensin receptor densities (NTR L ) in the frontal cortex and VEC, and more common QTL between these two phenotypes than expected by chance. This suggests a role for frontal cortex NTR L in regulating voluntary ethanol intake.
Databáze:	OpenAIRE
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