Chlamydia trachomatis Frequency in a Cohort of HPV-Infected Colombian Women
| Autor: | Dora I. Ríos-Chaparro, Ricardo Sánchez, Milena Camargo, Sara C. Soto-De Leon, Luisa Del Río-Ospina, Manuel E. Patarroyo, Juan David Ramírez, Edith Margarita Quinónez-Calvache, Manuel A. Patarroyo |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Envejecido
Prevalence Concurrent Sexual Partnership Artificial Gene Amplification and Extension No humano Pathology and Laboratory Medicine Polymerase Chain Reaction Geographical locations Papiloma Reacción en cadena de la polimerasa Human Papillomavirus Type 58 Chlamydia lcsh:Science Adolescente education.field_of_study Coinfection Bacterial Pathogens Población de alto riesgo Infecciones por chlamydia High Risk Population Sexual Partners Chlamydia Trachomatis Medical Microbiology Viral Pathogens Hacer un seguimiento Chlamydiasis Human Human Papillomavirus Infection Sexual transmission 030106 microbiology Sexually Transmitted Diseases Curso de Enfermedad Morbosidad Follow Up Colombia Microbiology HPV-16 Disease Course 03 medical and health sciences Infection Risk Estudio clínico principal Virus del papiloma humano tipo 58 Humans Human Papillomavirus Type 33 Infección mixta Infecciones por virus del papiloma Human Papillomavirus Type 31 Sexualidad Molecular Biology Techniques education Humano Microbial Pathogens Molecular Biology Cervix Parejas sexuales Aged papilomaviridae Bacteria Infecciones por clamidia Genitourinary Infections lcsh:R Organisms Gene Amplification Biology and Life Sciences Mixed Infection medicine.disease Virology Identificación de bacterias Enfermedades Clamidiasis Pareja sexual concurrente Virus del papiloma humano tipo 45 Riesgo de infección Immunology Human Papillomavirus Type 45 lcsh:Q Predominio People and places Morbidity Chlamydia trachomatis 0301 basic medicine Viral Diseases Enfermedades bacterianas lcsh:Medicine Adulto joven medicine.disease_cause Chlamydia Infection Virus del papiloma humano tipo 31 Human Papillomavirus Type 18 Virus del papiloma humano tipo 33 Human Papillomavirus Type 16 Medicine and Health Sciences Papillomaviridae Multidisciplinary biology Análisis de secuencia Isolation And Purification Middle Aged Infectious Diseases medicine.anatomical_structure Aislamiento y Purificación Amplificación de genes Viruses Female Pathogens Sequence Analysis Sexuality Cohort Analysis Research Article Adult Papillomaviruses Adolescent Urology Population Major Clinical Study Virus del papiloma humano tipo 16 Virus del papiloma humano tipo 18 Research and Analysis Methods Análisis de cohortes Young Adult Infección por virus del papiloma medicine Controlled Study Papillomavirus Infection business.industry Papillomavirus Infections Bacterium Identification Estudio controlado South America Chlamydia Infections biology.organism_classification Nonhuman Co-Infections Coinfección DNA viruses business |
| Zdroj: | PLoS ONE, Vol 11, Iss 1, p e0147504 (2016) Smith, J.S., Bosetti, C., Munoz, N., Herrero, R., Bosch, F.X., Eluf-Neto, J., Chlamydia trachomatis and invasive cervical cancer: A pooled analysis of the IARC multicentric case-control study (2004) International Journal of Cancer Journal International Du Cancer, 111 (3), pp. 431-439., Epub 2004/06/29. PMID: 15221973 Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Chlamydia trachomatis (C. trachomatis), an obligate intracellular bacterium, is the commonest infectious bacterial agent of sexual transmission throughout the world. It has been shown that the presence of this bacteria in the cervix represents a risk regarding HPV persistence and, thereafter, in developing cervical cancer (CC). Prevalence rates may vary from 2% to 17% in asymptomatic females, depending on the population being analysed. This study reports the identification of C. trachomatis in a cohort of 219 HPV-infected Colombian females. Methods C. trachomatis infection frequency was determined during each of the study’s follow-up visits; it was detected by amplifying the cryptic plasmid sequence by polymerase chain reaction (PCR) using two sets of primers: KL5/KL6 and KL1/KL2. Infection was defined as a positive PCR result using either set of primers at any time during the study. Cox proportional risk models were used for evaluating the association between the appearance of infection and a group of independent variables. Results Base line C. trachomatis infection frequency was 28% (n = 61). Most females infected by C. trachomatis were infected by multiple types of HPV (77.42%), greater prevalence occurring in females infected with HPV-16 (19.18%), followed by HPV-58 (17.81%). It was observed that females having had the most sexual partners (HR = 6.44: 1.59–26.05 95%CI) or infection with multiple types of HPV (HR = 2.85: 1.22–6.63 95%CI) had the greatest risk of developing C. trachomatis. Conclusions The study provides data regarding the epidemiology of C. trachomatis /HPV coinfection in different population groups of Colombian females and contributes towards understanding the natural history of C. trachomatis infection. © 2016 Quinónez-Calvache et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Databáze: | OpenAIRE |
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