Panton‐Valentine Leukocidin Is Not a Virulence Determinant in Murine Models of Community‐Associated Methicillin‐ResistantStaphylococcus aureusDisease
| Autor: | Amy M. Palazzolo-Ballance, Juliane Bubeck Wardenburg, Olaf Schneewind, Frank R. DeLeo, Michael Otto |
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| Rok vydání: | 2008 |
| Předmět: |
Staphylococcus aureus
Bacterial Toxins Leukocidin Exotoxins Virulence Skin infection Biology medicine.disease_cause Staphylococcal infections Article Microbiology Mice Leukocidins Pneumonia Staphylococcal medicine Animals Humans Immunology and Allergy skin and connective tissue diseases Mice Inbred BALB C respiratory system biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease Methicillin-resistant Staphylococcus aureus Virology Community-Acquired Infections Disease Models Animal Infectious Diseases Mutation bacteria Female Methicillin Resistance Staphylococcal Skin Infections Panton–Valentine leukocidin |
| Zdroj: | The Journal of Infectious Diseases. 198:1166-1170 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice. |
| Databáze: | OpenAIRE |
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