Effect of Methotrexate Therapy upon Choriocarcinoma and Chorioadenoma
| Autor: | Donald B. Spencer, Roy Hertz, Min C. Li |
|---|---|
| Rok vydání: | 1956 |
| Předmět: |
medicine.medical_specialty
Lung Neoplasms Dose medicine.drug_class Urinary system Gastroenterology General Biochemistry Genetics and Molecular Biology Pregnancy Internal medicine medicine Humans Choriocarcinoma Hydatidiform Mole Invasive business.industry medicine.disease Surgery Regimen Methotrexate Uterine Neoplasms Toxicity Folic Acid Antagonists Female Gonadotropin business medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 93:361-366 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-93-22757 |
| Popis: | Summary1) Two patients with choriocarcinoma and one with chorioadenoma destruens with proven progressive metastases were treated with methotrexate, a folic acid antagonist, according to intensive regimen of repeated courses of dosages producing substantial but reversible toxicity. Initially high urinary gonadotropin present in all 3 cases approached normal levels following this regimen and such low levels were sustained following cessation of treatment. 2) Unequivocal clinical improvement and radiological evidence of regression of pulmonary metastases was observed in all 3 cases. Nevertheless, extreme variations in pattern of clinical behavior of this type of tumor necessitate more observations before any definitive therapeutic implications may be drawn from these studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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