Persistent regulatory T-cell response 2 years after 3 years of grass tablet SLIT: Links to reduced eosinophil counts, sIgE levels, and clinical benefit
| Autor: | María M. Escribese, Francisco Vega, Santiago Martín, Tania Ramos, Ana C. Carrera, Alicia Marin, Rosa Varona, Peter Adler Würtzen, L Jimeno, Carlos Blanco, Agustin Galán, Domingo Barber |
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| Přispěvatelé: | Fundación Genoma España, ALK-Abelló Laboratories |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Regulatory T cell medicine.medical_treatment Immunology Poaceae T-Lymphocytes Regulatory Allergic rhinitis Immunophenotyping 03 medical and health sciences Leukocyte Count 0302 clinical medicine medicine Immunology and Allergy Humans Sublingual immunotherapy Interleukin 4 business.industry Rhinitis Allergic Seasonal IL‐4 Immunotherapy Regulatory T cells Eosinophil Allergens Immunoglobulin E Slit Discontinuation Clinical trial Eosinophils sIgG4 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Allergen‐Specific Immunotherapy and Biologics Leukocytes Mononuclear Pollen Original Article Female sIgE ORIGINAL ARTICLES business |
| Zdroj: | Allergy Digital.CSIC: Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | © 2018 The Authors. [Background]: In the first 2 years of grass tablet sublingual immunotherapy treatment, we have previously demonstrated a progressive development of a regulatory T‐cell response, which was preceded by an early decrease in the frequency of both IL‐4+ cells and sIgE levels. A progressive increase in sIgG4 levels and FAB blockage were also found. [Methods]: By monitoring immunological kinetics during 3 years of active treatment + 2 years of follow‐up, we aimed to identify key immunological parameters that could explain sustained clinical benefit of grass tablet sublingual immunotherapy. [Results]: Thirty patients completed the 5‐year clinical trial protocol. Although individual responses were heterogeneous, reduction in both sIgE and circulating IL‐4+ cells compared to the initial 1‐ to 4‐month peak was maintained throughout the 3‐year treatment period and for 2 years after discontinuation. Meanwhile, after a 2‐year increase in sIgG4, the levels were stabilized during the third year and decreased post‐therapy. FAB inhibition remained significantly inhibited throughout the study compared to preimmunotherapy in 83% of patients. A sustained regulatory T‐cell response, after IT cessation, occurs in two‐thirds of the patients. There was a statistical association between this regulatory response, the maintenance of lower eosinophil counts during grass pollen seasons, and sIgE titers lower than before immunotherapy treatment, and the latter were significantly associated with clinical response. [Conclusion]: Our results suggest that the immunological mechanisms underlying the sustained response after 2 years of cessation of immunotherapy (3‐year treatment period) are linked to the acquisition and maintenance of a regulatory T‐cell response. This work was supported by Genoma España and ALK‐Abello A/S. |
| Databáze: | OpenAIRE |
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