Prospective Comparison of Reduced-Iodine-Dose Virtual Monochromatic Imaging Dataset From Dual-Energy CT Angiography With Standard-Iodine-Dose Single-Energy CT Angiography for Abdominal Aortic Aneurysm
| Autor: | Ronald S. Arellano, George R. Oliveira, Mukta Agrawal, Daniella F. Pinho, Sanjeeva P. Kalva, Dushyant V. Sahani |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Aortography Computed Tomography Angiography Image quality Contrast Media 030204 cardiovascular system & hematology Radiation Dosage Sensitivity and Specificity 030218 nuclear medicine & medical imaging Radiography Dual-Energy Scanned Projection User-Computer Interface 03 medical and health sciences Radiation Protection 0302 clinical medicine Iodinated contrast medicine Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Aged Computed tomography angiography Aged 80 and over Dose-Response Relationship Drug medicine.diagnostic_test business.industry Reproducibility of Results General Medicine Middle Aged Radiation Exposure medicine.disease Abdominal aortic aneurysm Radiographic Image Enhancement Angiography Female Radiology Monochromatic color business Aortic Aneurysm Abdominal Iodine |
| Zdroj: | American Journal of Roentgenology. 207:W125-W132 |
| ISSN: | 1546-3141 0361-803X |
| DOI: | 10.2214/ajr.15.15814 |
| Popis: | The purpose of this study was to compare the image quality of reduced-iodine-dose single-source dual-energy CT angiography (CTA) with that of standard-iodine-dose single-energy CTA in examinations of patients with abdominal aortic aneurysm and to assess the effect of the concentration of iodinated contrast medium on intravascular enhancement and image quality of reduced-iodine-dose CTA.In a prospective randomized clinical trial, 66 consecutively registered patients with abdominal aortic aneurysm who had previously undergone single-energy CTA (30-37 g I) underwent follow-up CTA at a reduced dose (21-27 g I) of iodinated contrast medium of either 270 mg I/mL (n = 33) or 320 mg I/mL (n = 33). Two readers independently evaluated virtual monochromatic imaging datasets (40-140 keV) and single-energy CTA images for image quality and noise and their preference for optimal energy virtual monochromatic imaging dataset. A value of p0.05 was considered statistically significant.All 66 dual-energy CTA examinations were rated diagnostic with mean image quality and image noise scores of 4.8 and 4.5 for reader 1 and 3.8 and 3.4 for reader 2 compared with single-energy CTA results of 4.5 and 4.2 for reader 1 and 4.5 and 4.1 for reader 2. Low-energy virtual monochromatic images (40-60 keV) from reduced-iodine-dose (28%) dual-energy CTA had significantly higher intravascular aortic attenuation (26-185%) and contrast-to-noise ratio (CNR) (20-25%) than standard-iodine-dose single-energy CTA images (p0.0001). No significant difference was found between patients who received 270 and those who received 320 mg I/mL with respect to intravascular aortic attenuation (p = 0.6331) or CNR (p = 0.9775).Low-energy virtual monochromatic imaging datasets from reduced-iodine (24 g I) single-source dual-energy CTA of the abdomen provide up to 185% higher attenuation and 25% higher CNR than standard-iodine-dose (33.3 g I) single-energy CTA while offering a wide range of energy settings irrespective of the concentration of IV contrast medium used. |
| Databáze: | OpenAIRE |
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