Quercetin supplementation suppresses the secretion of pro-inflammatory cytokines in the lungs of Mongolian gerbils and in A549 cells exposed to benzo[a]pyrene alone or in combination with β-carotene: in vivo and ex vivo studies
| Autor: | Shu-Ting Chan, Jiunn-Wang Liao, Miao-Ju Tseng, Cheng-Hung Chuang, Shu-Lan Yeh, Kai-Li Liu, Chiao-Lin Yeh |
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| Rok vydání: | 2012 |
| Předmět: |
Male
animal structures MAP Kinase Kinase 4 Endocrinology Diabetes and Metabolism Interleukin-1beta Clinical Biochemistry Inflammation Pharmacology Biochemistry Proinflammatory cytokine chemistry.chemical_compound In vivo Cell Line Tumor Benzo(a)pyrene polycyclic compounds medicine Animals Humans heterocyclic compounds Lung Molecular Biology A549 cell Nutrition and Dietetics Tumor Necrosis Factor-alpha JNK Mitogen-Activated Protein Kinases beta Carotene Gene Expression Regulation Liver chemistry Dietary Supplements Cytokines Quercetin Tumor necrosis factor alpha medicine.symptom Gerbillinae Bronchoalveolar Lavage Fluid Ex vivo |
| Zdroj: | The Journal of Nutritional Biochemistry. 23:179-185 |
| ISSN: | 0955-2863 |
| DOI: | 10.1016/j.jnutbio.2010.11.014 |
| Popis: | In vitro studies have shown that quercetin modulates the effects of β-carotene induced by stimulants. Whether these reactions happen in vivo, however, is unclear. Thus, we investigated whether quercetin supplementation suppresses the harmful effects of benzo[a]pyrene (BaP) alone or combined with β-carotene in the lungs of Mongolian gerbils. The gerbils were given quercetin (100 mg/kg body wt, 3 times/week), β-carotene (10 mg/kg body wt, 3 times/week), and BaP (8 mmol, 2 times/week) alone or in combination by gavage for 6 months. β-Carotene supplementation enhanced the pro-inflammatory effects of BaP in the lungs of gerbils. In contrast, quercetin supplementation significantly decreased the infiltration of inflammatory cells as well as the levels of TNF-α and IL-1β in the bronchoalveolar lavage fluid and plasma of gerbils exposed to BaP or BaP+β-carotene (P |
| Databáze: | OpenAIRE |
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