Exaggerated ANF response to exercise in middle-aged vs. young runners
| Autor: | B. J. Freund, John R. Claybaugh, Michael J. Buono, S. Chrisney, G. M. Hashiro |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Aging Vasopressin medicine.medical_specialty Vasopressins Physiology Physical exercise Plasma renin activity Running chemistry.chemical_compound Atrial natriuretic peptide Heart Rate Physiology (medical) Internal medicine Renin Heart rate medicine Humans Aldosterone Exercise business.industry Osmolar Concentration Sodium Middle Aged Plasma osmolality Endocrinology chemistry Physical Endurance Female business Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists Antidiuretic |
| Zdroj: | Journal of Applied Physiology. 69:1607-1614 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1990.69.5.1607 |
| Popis: | Hormonal, electrolyte, and renal responses were measured before, during, and after a marathon (42.2 km) in 14 runners: 8 young (Y) (mean age 27.8 yr) and 6 middle aged (MA) (mean aged 46.7 yr). No differences between groups in prerun values for heart rate (HR), plasma osmolality (OSM), antidiuretic hormone (ADH), aldosterone (ALDO), atrial natriuretic factor (ANF), or plasma renin activity (PRA) were found. Renal and urinary measurements were also similar between groups before the marathon. After 10 km of running, both groups had significant increases in HR, ALDO, ANF, and PRA, while OSM, Na+, and ADH remained unchanged from prerun values. The increase in plasma ANF concentrations at this point was significantly greater in the MA subjects compared with the Y (mean increase 104.1 vs. 42.8 pg/ml, respectively; P less than 0.01). Immediate postmarathon values for OSM, ADH, and Na+ were significantly higher than initial values in both groups, while HR, PRA, and ALDO continued to increase above the elevated levels found at 10 km. ANF values immediately postmarathon remained higher than prerun concentrations but were significantly reduced from those obtained at 10 km. In contrast, HR continued to rise until the completion of the run. These data are consistent with recent reports of an exaggerated ANF response in older subjects in response to central blood volume expansion. |
| Databáze: | OpenAIRE |
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