Effects of N omega-nitro-L-arginine and capsaicin on neurogenic vasomotor responses in isolated mesenteric arteries of the monkey
| Autor: | Tony J.-F. Lee, Ryuich Yamamoto, Masanobu Urabe, Kimiyuki Tsuchiya, Yujiro Asada |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Calcitonin Gene-Related Peptide Pharmaceutical Science Vasodilation Biology In Vitro Techniques Arginine Nitric Oxide Nitroarginine Nitric oxide chemistry.chemical_compound Internal medicine medicine Animals Mesenteric arteries Pharmacology Vasomotor Haplorhini Mesenteric Arteries Endocrinology medicine.anatomical_structure chemistry Vasoconstriction Circulatory system Prostaglandins Female medicine.symptom Capsaicin Blood vessel |
| Zdroj: | The Journal of pharmacy and pharmacology. 46(2) |
| ISSN: | 0022-3573 |
| Popis: | Monkey isolated mesenteric arterial rings denuded of endothelium constricted upon transmural nerve stimulation (TNS) in the absence of active muscle tone. The constriction was potentiated by Nω-nitro-l-arginine (3 × 10−5 m), but not by the d-enantiomer (3 × 10−5 m). The potentiation was reversed by l-arginine (3 × 10−4 m). The neurogenic vasoconstriction of mesenteric arteries was also augmented by capsaicin, but to a lesser extent than that induced by Nω-nitro-l-arginine. Indomethacin (10−5 m) did not affect TNS-induced vasoconstriction. These findings suggest that nerve-derived nitric oxide or a related substance may play a greater role than do capsaicin-sensitive vasodilator transmitters in neurogenic regulation of mesenteric arterial tone in the monkey. The transmitter mechanisms for vasodilation in mesenteric circulation vary among species. |
| Databáze: | OpenAIRE |
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